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Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis

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Abstract

To assess potential interactions of multiple drug regimens administered to patients with AIDS for toxicity and efficacy, we reviewed the charts of 35 patients on maintenance therapy for toxoplasmosis. Seven relapses of toxoplasmosis occurred in 6 of 35 (17 %) patients, and seven episodes of pneumocystosis occurred in 6 of 35 (17 %) patients. Four relapses of toxoplasmosis and 5 relapses of pneumocystosis were seen in 20 patients treated with pyrimethamine/clindamycin; 2 relapses of toxoplasmosis and 2 relapses of pneumocystosis were seen in 11 patients treated with pyrimethamine alone, and 1 relapse of toxoplasmosis was seen in 13 patients treated with pyrimethamine/sulfadiazine. Adverse effects were related to pyrimethamine in 10 patients, to clindamycin in 7 patients, and to sulfadiazine in 8 patients. These results must be compared with those of prospective trials to determine the efficacy and safety of various maintenance regimens.

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References

  1. Girard PM, Lepretre A, Detruchis P, Matheron S, Coulaud JP Failure of pyrimethamine-clindamycin combination for prophylaxis ofPneumocystis carinii pneumonia. Lancet 1989, ii: 1459.

    Google Scholar 

  2. Leport C, Raffi F, Matheron S, Katlama C, Regnier B, Saimot AG, Marche C, Vedrenne C, Vildé JL Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with the acquired immunodeficiency syndrome: efficacy of long-term continuous therapy. American Journal of Medicine 1988, 84: 94–100.

    PubMed  Google Scholar 

  3. Masur H, Lane HC, Kovacs JA, Allegra CJ, Edman JC Pneumocystis pneumonia: from bench to clinic. Annals of Internal Medicine 1989, 111: 813–826.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Service des Maladies Infectieuses et Tropicales, Hôpital Bichat-Claude Bernard, 46 rue Henri Huchard, 75877, Paris Cedex 18, France

    C. Leport, C. Tournerie, G. Raguin, J. Fernandez-Martin, T. Niyongabo & J. L. Vildé

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  1. C. Leport
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  2. C. Tournerie
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  3. G. Raguin
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  4. J. Fernandez-Martin
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  5. T. Niyongabo
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  6. J. L. Vildé
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Leport, C., Tournerie, C., Raguin, G. et al. Long-term follow-up of patients with AIDS on maintenance therapy for toxoplasmosis. Eur. J. Clin. Microbiol. Infect. Dis. 10, 191–193 (1991). https://doi.org/10.1007/BF01964460

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  • DOI: https://doi.org/10.1007/BF01964460

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