Evaluation of the efficacy and safety of clindamycin plus pyrimethamine for induction and maintenance therapy of toxoplasmic encephalitis in AIDS
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Through the European Network in the Treatment of AIDS, a multicenter trial is being conducted to compare the efficacy and safety of pyrimethamine (50 mg/day) plus clindamycin (2.4 g/day) with the regimen of pyrimethamine (50 mg/day) and sulfadiazine (4.0 g/day) for induction and maintenance treatment of toxoplasmic encephalitis. By 1 September 1990, 281 patients had been randomized to enter the study. Preliminary data show that 77 % of the 148 patients evaluated showed a complete response or improvement with minor sequelae during therapy. Twenty percent of the patients deteriorated. This was due to toxoplasmosis in only 10 % of the patients. Side-effects were common in all patients regardless of treatment regimen and consisted mainly of rash (52 cases), fever (31 cases), diarrhea (17 cases) and nausea (12 cases). The final analysis should be available by the middle of 1991.
KeywordsInternal Medicine Diarrhea Treatment Regimen Encephalitis Final Analysis
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- 1.Remington JS, Desmonts G Toxoplasmosis. In: Remington JS, Klein JO (ed): Infectious diseases of the fetus and newborn infant. Saunders, Philadelphia, 1990, p. 89–195.Google Scholar
- 2.Grant IH, Gold JWM, Armstrong D: Risk of CNS toxoplasmosis in patients with acquired immune deficiency syndrome. In: Program and Abstracts of the 26th Interscience Conference of Antimicrobial Agents and Chemotherapy, New Orleans, 1986, Abstract no. 441.Google Scholar
- 3.Leport C, Raffi F, Matheron S, Katlama C, Regnier B, Saimot AG, Marche C, Vedrenne C, Vildé JL Treatment of central nervous system toxoplasmosis with pyrimethamine/sulfadiazine combination in 35 patients with acquired immunodeficiency syndrome: efficacy of long term continuous therapy. American Journal of Medicine 1988, 84: 94–100.PubMedGoogle Scholar
- 8.Tedesco FJ Clindamycin and colitis: a review. Journal of Infectious Diseases 1977, 135, Supplement: 95–98.Google Scholar