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Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin

  • New Antimicrobial Agents
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Abstract

Five fluoroquinolones were tested against 300 staphylococci from a wide variety of US medical centers including 150 strains resistant to penicil-linase-resistant penicillins (PRP-resistant). Ten ciprofloxacin-resistant strains of PRP-resistantStaphylococcus aureus were relatively resistant to the other fluoroquinolones, but the remaining 290 isolates were susceptible to all five drugs at established or anticipated breakpoint concentrations. The relative potency of the study drugs could be ranked as follows: CI-960>PD 131628>sparfloxacin > ciprofloxacin > ofloxacin. All five drugs were bactericidal against PRP-resistant and PRP-susceptible staphylococci.

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Authors and Affiliations

  1. The Clinical Microbiology Institute, PO Box 947, 97062, Tualatin, Oregon, USA

    A. L. Barry

  2. St. Vincent Hospital and Medical Center, 97225, Portland, Oregon, USA

    P. C. Fuchs

Authors
  1. A. L. Barry
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  2. P. C. Fuchs
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Barry, A.L., Fuchs, P.C. Antistaphylococcal activity of the fluoroquinolones CI-960, PD 131628, sparfloxacin, ofloxacin and ciprofloxacin. Eur. J. Clin. Microbiol. Infect. Dis. 10, 168–171 (1991). https://doi.org/10.1007/BF01964451

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  • DOI: https://doi.org/10.1007/BF01964451

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