Summary
After i.v. administration to rats of polysaccharide-protein complex, isolated fromCandida albicans, a decrease of cardiac output was observed from 20 sec to 240 min postinjection, followed by a recovery at 360 min. Concomitantly the regional blood flow was maintained in heart and lungs, moderately decreased in intestine, liver and adrenals and markedly reduced in skin, muscle, spleen and kidney.
Similar content being viewed by others
References
J.E. Cutler, L. Friedman and K.C. Milner, Infect. Immunity6, 616 (1972).
P. Švec, J. Hyg. Epidem. Microbiol. Immun.18, 373 (1974).
T. Trnovec, Š. Bezek, A. Gajdošík and D. Šikl, Circul. Shock5, 51 (1978).
R. Nosáľ, J. Novotný and D. Šikl Toxicon12, 103 (1974).
D. Šikl, L. Masler, Š. Bauer, J. Šandula, A. Tomšíková and V. Zavázal, Z. ImmunForsch. exp. Ther.138, 207 (1969).
L. Takács, K. Kállay and J.H. Skolnik, Circulation Res.10, 753 (1962).
L.A. Sapirstein, Am. J. Physiol.193, 161 (1958).
R. Nosáľ, Proc. 6th Int. Spec. Symp. Yeasts, Montpellier, France, p. LIV 1. Ed. Chair Genet. Microbiol., Ensam-Cram 1978.
R. Nosáľ and Z. Menyhardtová, Toxicon14, 313 (1976).
K. Okada, I. Kosugi, T. Kitagaki, Y. Yamaguchi, H. Yoshikawa, Y. Kawashima, S. Kawakami and Y. Senoh, Jap. Circul. J.41, 346 (1977).
R.P. Gilbert, Physiol. Rev.40, 245 (1960).
F. Wyler, J.M. Neutze and A.M. Rudolph, Am. J. Physiol.219, 246 (1970).
J.L. Ferguson, G.F. Merrill, H.I. Miller and J.J. Spitzer, Circul. Shock4, 317 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Nosáľová, V., Trnovec, T., Gregušková, M. et al. The effect of polysaccharide-protein complex isolated fromCandida albicans on regional blood flow in rats. Experientia 35, 341–342 (1979). https://doi.org/10.1007/BF01964340
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01964340