Summary
The conversion of cholesterol into 19-nor-5α-cholestan-3β-ol by the spongeAxinella polypoides involves a partial loss (40%) of the 3α-hydrogen atom; moreover administration to the sponge of [4-14C]cholesterol tritiated at C-4β and C-7 showed that the 4β- and 7-hydrogen atoms are retained in this conversion. A competitive uptake experiment, [4-14C]cholesterol vs. [7-3H2]5α-cholestanol, showed that the sponge utilized exclusively cholesterol for the production of 19-nor-5α-cholestan-3β-ol.
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Part of this work has been presented at the Nato Conference on Marine Natural Products (Jersey, Great Britain, October, 1976).-This contribution is part of the Programma finalizzato ‘Oceanografia e Fondi marini-sottoprogetto Risorse biologiche’ C.N.R. Italy.
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Minale, L., Persico, D. & Sodano, G. Metabolism in Porifera. IX. Studies on the biological conversion of cholesterol into 19-nor-cholestanol by the spongeAxinella polypoides. Experientia 35, 296–297 (1979). https://doi.org/10.1007/BF01964307
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DOI: https://doi.org/10.1007/BF01964307