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Comparative in vitro activity of the two new 4-quinolones S-25930 and S-25932 against gram-positive bacteria isolated from cancer patients

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The in vitro activity of S-25930 and S-25932, two new quinolone antimicrobial agents, against 306 gram-positive organisms representing 12 bacterial species, was evaluated and compared with the activity of ciprofloxacin, difloxacin, enoxacin, amifloxacin and A-56620. Both agents were active against staphylococcal species (including methicillin-resistant and coagulase-negative isolates),Bacillus spp. and group JK diphtheroids. They were less active against streptococcal species andListeria monocytogenes. Their activity against most isolates was superior to that of amifloxacin, enoxacin and difloxacin and similar to that of ciprofloxacin and A-56620.

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Authors and Affiliations

  1. Section of Infectious Diseases, Department of Medical Specialties, University of Texas System Cancer Center, 1515 Holcombe Boulevard, Box 47, 77030, Houston, Texas, USA

    K. V. I. Rolston, D. H. Ho, B. LeBlanc & G. P. Bodey

Authors
  1. K. V. I. Rolston
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  2. D. H. Ho
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  3. B. LeBlanc
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  4. G. P. Bodey
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Rolston, K.V.I., Ho, D.H., LeBlanc, B. et al. Comparative in vitro activity of the two new 4-quinolones S-25930 and S-25932 against gram-positive bacteria isolated from cancer patients. Eur. J. Clin. Microbiol. Infect. Dis. 7, 681–683 (1988). https://doi.org/10.1007/BF01964254

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  • DOI: https://doi.org/10.1007/BF01964254

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