References
Green, G. M., Kass, E. H. The role of the alveolar macrophage in the clearance of bacteria from the lung. Journal of Experimental Medicine 1963, 119: 167–175.
Onoforio, J. M., Toews, G. B., Lipscomb, M. F., Pierce, A. K. Granulocyte-alveolar macrophage interaction in the pulmonary clearance ofStaphylococcus aureus. American Review of Respiratory Disease 1983, 127: 337–341.
Wewers, M. D., Rennard, S. I., Hance, A. J., Bitterman, P. B., Crystal, R. G. Normal human alveolar macrophages obtained by bronchoalveolar lavage have a limited capacity to release interleukin-1. Journal of Clinical Investigation 1984, 74: 2208–2218.
Hunninghake, G. W., Gadek, J. E., Fales, H. M., Crystal, R. G. Human alveolar macrophage-derived chemotactic factor for neutrophils. Journal of Clinical Investigation 1980, 6: 473–484.
Reynolds, H. Y., Atkinson, J. P., Newball, H. H., Frank, M. M. Receptors for immunoglobulin and complement on human alveolar macrophages. Journal of Immunology 1975, 114: 1813–1819.
Klebanoff, S. J. Oxygen metabolism and the toxic properties of phagocytes. Annals of Internal Medicine 1980, 93: 480–489.
Catterall, J. R., Sharma, S. D., Remington, J. S. Oxygen-dependent killing by alveolar macrophages. Journal of Experimental Medicine 1986, 163: 1113–1130.
Hibbs, J. B., Taintor, R. R., Vavrin, Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrate. Science 1987, 235: 473–476.
Toews, G. B., Vial, W. C., Dunn, M. M., Guzzetta, P., Nunez, G., Stastny, P., Lipscomb, M. F. The accessory cell function of human alveolar macrophages in specific T-cell proliferation. Journal of Immunology 1984, 132: 181–186.
Jensen, W. A., Rose, R. M., Burke, R. H., Anton, K., Remold, H. G. Cytokine activation of antibacterial activity in human pulmonary macrophages: comparison of recombinant interferon-gamma and granulocyte macrophage-colony stimulating factor. Cellular Immunology 1988, 117 (2): 369–377.
Douvas, G. S., Looker, D. L., Vatter, A. E., Crowle, A. J. Gamma interferon activates human macrophages to become tumorcidal and leishmanicidal but enhances replication of macrophage-associated mycobacteria. Infection and Immunity 1985, 80: 1–8.
Wing, E. J., Ampel, N. M., Waheed, A., Shadduck, R. K. Macrophage colony-stimulating factor (M-CSF) enhances the capacity of murine macrophages to secrete oxygen reduction products. Journal of Immunology 1985, 135: 2052.
Rose, R. M., Wasserman, A. S., Weiser, W. Y., Remold, H. G. Deficient responses of pulmonary macrophages from healthy smokers to antiviral lymphokines in vitro. Journal of Infectious Diseases 1986, 154 (4): 611–618.
Jakab, G. J., Green, G. M. Defect in intracellular killing ofStaphylococcus aureus within alveolar macrophages in Sendai virus infected murine lungs. Journal of Clinical Investigation 1986, 57: 1533–1539.
Jakab, G. J., Warr, G. A. Immune enhanced phagocytic dysfunction in pulmonary macrophages infected with parainfluenza 1 (Sendai) virus. American Review of Respiratory Disease 1981, 124: 575–581.
Jakab, G. J., Warr, G. A. Lung defenses against viral and bacterial challenges during immunosuppression with cyclophosphamide in mice. American Review of Respiratory Disease 1981, 123: 524–528.
Smith, P. D., Ohura, K., Masur, H., Lane, H. C., Fauci, A. S., Wahi, S. M. Monocyte function in the acquired immune deficiency syndrome. Journal of Clinical Investigation 1984, 74: 2121–2128.
Salahuddin, Z. A., Rose, R. M., Groopman, J. E., Markham, P. D., Gallo, R. C. Infection of human pulmonary macrophages with HTLV-III. Blood 1986, 68: 281–284.
Chayt, K. J., Harper, M. E., Lewin, E. B., Rose, R. M., Marselle, L. M., Oleske, J. M., Epstein, L. G., Wong-Staal, F., Gallo, R. C. Detection of HTLV-III RNA in lungs of patients with the acquired immunodeficiency syndrome and pulmonary involvement. Journal of the American Medical Association 1986, 256: 2356–2359.
Pennington, J. E., Harris, E. A. Influence of immunosuppression on alveolar macrophage chemotactic activities in guinea pigs. American Review of Respiratory Disease 1981, 123: 299–304.
Pennington, J. E., Matthews, W. J., Marino, E. J., Colten, H. R. Cyclophosphamide and cortisone acetate inhibit complement biosynthesis by guinea pig bronchoalveolar macrophages. Journal of Immunology 1979, 123: 1318–1321.
Szuro-Sudol, A., Nathan, C. F. Suppression of macrophage oxidative metabolism by products of malignant and nonmalignant cells. Journal of Experimental Medicine 1982, 156: 945–961.
Nathan, C. F., Kaplan, G., Levis, W. R., Nusrat, A., Witmer, M. D., Sherwin, S. A., Job, C. K., Horowitz, C. R., Steinman, R. M., Cohn, Z. A. Local and systemic effects of low doses of recombinant interferon-gamma after intradermal injection in patients with lepromatous leprosy. New England Journal of Medicine 1986, 315: 6–14.
Ezekowitz, R. A. B., Dinauer, M. C., Jaffe, H. S., Orkin, S. H., Newburger, P. E. Partial correction of the phagocyte defect in patients with x-linked chronic granulomatous disease by subcutaneous interferon-gamma. New England Journal of Medicine 1988, 319: 146–151.
Brandt, S. J., Peters, W. P., Atwater, S. K., Kurtzberg, J., Borowitz, M. J., Jones, R. B., Shpall, E. J., Bast, R. C., Gilbert, C. J., Oette, D. H. Effect of recombinant human granulocyte-macrophage colony stimulating factor on hematopoietic reconstitution after high-dose chemotherapy and autologous bone marrow transplantation. New England Journal of Medicine 1988, 318: 869–876.
Debs, R. J., Fuchs, H. J., Philip, R., Montgomery, A. B., Brunette, E. N., Liggitt, D., Patton, J. S., Shellito, J. E. Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats. Journal of Immunology 1988, 140: 3482–3488.
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Rose, R.M. Pulmonary macrophages in nosocomial pneumonia: Defense function and dysfunction, and prospects for activation. Eur. J. Clin. Microbiol. Infect. Dis. 8, 25–28 (1989). https://doi.org/10.1007/BF01964116
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DOI: https://doi.org/10.1007/BF01964116