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Mianserin reduces plasma levels ofβ-endorphin immunoreactivity in depressed patients

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Summary

Eight depressed patients were treated for 25 days with the antidepressant drug mianserin (3×20 mg/day). °-Endorphin immunoreactivity, measured in blood samples withdrawn before and after the treatment, appeared to be significantly reduced by mianserin. Since endogenous opioids can play a role in the etiology of depression, the observed effects of mianserin could be of relevance for its anti-depressant activity.

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Authors and Affiliations

  1. Institute of Pharmacology, University of Catania Medical School, Viale A. Doria 6, I-95125, Catania, Italy

    F. Drago, V. M. Wiegant, G. Sapienza, E. Aguglia, V. Rapisarda & U. Scapagnini

  2. Rudolf Magnus Institute for Pharmacology, State University of Utrecht, Vondellaan 6, NL-3521 GD, Utrecht, The Netherlands

    F. Drago, V. M. Wiegant, G. Sapienza, E. Aguglia, V. Rapisarda & U. Scapagnini

  3. Psychiatric Clinic, University of Catania Medical School, Viale A. Doria 6, I-95125, Catania, Italy

    F. Drago, V. M. Wiegant, G. Sapienza, E. Aguglia, V. Rapisarda & U. Scapagnini

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  1. F. Drago
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  2. V. M. Wiegant
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  3. G. Sapienza
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  4. E. Aguglia
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  5. V. Rapisarda
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  6. U. Scapagnini
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Drago, F., Wiegant, V.M., Sapienza, G. et al. Mianserin reduces plasma levels ofβ-endorphin immunoreactivity in depressed patients. Experientia 38, 685–686 (1982). https://doi.org/10.1007/BF01964095

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  • DOI: https://doi.org/10.1007/BF01964095

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