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Experientia

, Volume 38, Issue 6, pp 655–657 | Cite as

Hydrophobic properties of model compounds with peptide-like chemical environment: N-acetyl-N′-methyl-amino acid amides

  • H. J. Wynne
  • K. H. Van Buuren
  • W. Wakelkamp
Article

Summary

Capacity factors in reversed-phase HPLC and distribution constants in octan-l-ol/water of N-acetyl-N′-methylamino acid amides have been measured as a function of temperature. The HPLC capacity factors are proposed as estimates of the hydrophobicity of the amino acid side chains.

Keywords

HPLC Amide Chemical Environment Model Compound Capacity Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser-Verlag 1982

Authors and Affiliations

  • H. J. Wynne
    • 1
  • K. H. Van Buuren
    • 1
  • W. Wakelkamp
    • 1
  1. 1.Department of Pharmaceutical ChemistryUniversity of AmsterdamAmsterdam(The Netherlands)

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