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The principal toxin ofDelphinium brownii Rydb., and its mode of action

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Summary

Examination ofD. brownii, a stock-poison of Western Canada, revealed that the principal toxin was methyllycaconitine: a potent neuromuscular blocking agent which appears to act competitively at nicotinic receptors.

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Authors and Affiliations

  1. Department of Biology, The University of Calgary, T2N 1N4, Calgary, Alberta, Canada

    V. Nambi Aiyar, M. H. Benn, T. Hanna, J. Jacyno, S. H. Roth & J. L. Wilkens

  2. Department of Chemistry, The University of Calgary, T2N 1N4, Calgary, Alberta, Canada

    V. Nambi Aiyar, M. H. Benn, T. Hanna, J. Jacyno, S. H. Roth & J. L. Wilkens

  3. Department of Pharmacology and Therapeutics, The University of Calgary, T2N 1N4, Calgary, Alberta, Canada

    V. Nambi Aiyar, M. H. Benn, T. Hanna, J. Jacyno, S. H. Roth & J. L. Wilkens

Authors
  1. V. Nambi Aiyar
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  2. M. H. Benn
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  3. T. Hanna
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  4. J. Jacyno
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  5. S. H. Roth
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  6. J. L. Wilkens
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Additional information

We thank the University of Calgary, The National Research Council of Canada, and the Alberta Agriculture Department, for financial assistance.

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Aiyar, V.N., Benn, M.H., Hanna, T. et al. The principal toxin ofDelphinium brownii Rydb., and its mode of action. Experientia 35, 1367–1368 (1979). https://doi.org/10.1007/BF01964013

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  • DOI: https://doi.org/10.1007/BF01964013

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