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Globin gene expression in MSV-transformed fibroblasts

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Summary

The activation of globin gene expression on viral transformation of 3T3 cells was investigated. Globin mRNA was determined using a radioactive complementary DNA probe. No difference was found between 3T3 and transformed 3T3 cells. There does not therefore appear to be a random activation of extensive regions of the cellular genome.

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Author notes

  1. W. Fitschen

    Present address: Department of Medical Biochemistry, University of the Witwatersrand, Medical School, 2001, Johannesburg, South Africa

Authors and Affiliations

  1. Department of Biochemistry, University of Cape Town, 7700, Rondebosch, South Africa

    I. Parker & W. Fitschen

Authors
  1. I. Parker
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  2. W. Fitschen
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Additional information

We wish to thank Dr J.W. Beard for supplying the AMV reverse transcriptase. This work was supported by grants from the CSIR and the University of Cape Town Research Committee.

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Parker, I., Fitschen, W. Globin gene expression in MSV-transformed fibroblasts. Experientia 35, 1312–1313 (1979). https://doi.org/10.1007/BF01963978

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