Skip to main content
Log in

The influence of insulin, cAMP and the calcium ionophore X 537 A on the growth of the cartilage anlagen of limb buds in vitro

  • Specialia
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Limb buds of 11-day-old mouse embryos were cultured for 6 days with insulin, dibutyryl cAMP and X 537 A. The cartilage anlage was reduced by insulin and enlarged by dibutyryl cAMP and X 537 A. The effects are due to changes in the amount of intercellular substance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. D.L. Friedman, Physiol. Rev.56, 652 (1976).

    Article  CAS  PubMed  Google Scholar 

  2. I.H. Pastan, G.S. Johnson and W.B. Anderson, A. Rev. Biochem.44, 491 (1975).

    Article  CAS  Google Scholar 

  3. D.L. Friedman, R.A. Johnson and C.E. Zeilig, Adv. Cycl. Nucl. Res.7, 69 (1976).

    CAS  Google Scholar 

  4. H.D. Peters, K. Karzel, D. Padberg, P.S. Schönhöfer and V. Dinnendahl, Pol. J. Pharmac. Pharm.26, 41 (1974).

    CAS  Google Scholar 

  5. M. Shinmei, P. Ghosh and T.K.F. Taylor, Biochim. biophys. Acta,437, 94 (1974).

    Article  Google Scholar 

  6. C.W. Castor, J. lab. clin. Med.83, 46 (1974).

    Google Scholar 

  7. M. Tomida, H. Koyama and T. Ono, Biochem. J.162, 539 (1977).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. G. Manner and M. Kuleba, Connect. Tissue Res.2, 167 (1974).

    Article  CAS  PubMed  Google Scholar 

  9. M.B. Aydelotte and D. Kochhar, Devl Biol.28, 191 (1972).

    Article  CAS  Google Scholar 

  10. D. Neubert, H.-J. Merker and S. Tapken, Naunyn-Schmiedebergs Arch. Pharmac.286, 251 (1974).

    Article  CAS  Google Scholar 

  11. B.C. Pressman, Fed. Proc.32, 1698 (1973).

    CAS  PubMed  Google Scholar 

  12. A.B. Borle and R. Studer, J. membr. Biol.38, 51 (1978).

    Article  CAS  PubMed  Google Scholar 

  13. H. Rasmussen and D.B.P. Goodman, Physiol. Rev.57, 421 (1977).

    Article  CAS  PubMed  Google Scholar 

  14. L.S. Bradham, D.A. Holt and M. Sims, Biochim. biophys. Acta201, 250 (1970).

    Article  CAS  PubMed  Google Scholar 

  15. C.O. Brostrom, Y.-C. Huang, B.M. Breckenridge and D.J. Wolff, Proc. nat. Acad. Sci.72, 64 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. W.Y. Cheung, L.S. Bradham, T.J. Lynch, M.Y. Lin and E.A. Tallant, Biochem. biophys. Res. Commun.66, 1055 (1975).

    Article  CAS  PubMed  Google Scholar 

  17. S. Kakiuchi, R. Yamazaki, Y. Teshima and K. Uenishi, Proc. nat. Acad. Sci.70, 3526 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Th. Günther and R. Averdunk, J. clin. Chem. clin. Biochem.14, 365 (1976).

    PubMed  Google Scholar 

  19. N. Friedmann and C.R. Park, Proc. nat. Acad. Sci.61, 504 (1968).

    Article  CAS  PubMed Central  Google Scholar 

  20. R. Dulbecco and J. Elkington, Proc. nat. Acad. Sci.72, 1584 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. M.H. Gail, Ch.W. Boone and C.S. Thompson, Exp. Cell Res.79, 386 (1973).

    Article  CAS  PubMed  Google Scholar 

  22. S.D. Balk, J.F. Whitfield, T. Youdale and A.C. Braun, Proc. nat. Acad. Sci.70, 675 (1973).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. J.W. Craig, T.W. Rall and J. Larner, Biochim. biophys. Acta177, 213 (1969).

    Article  CAS  PubMed  Google Scholar 

  24. W.A. Gavryck, R.D. Moore and R.C. Thompson, J. Physiol.252, 43 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. T.J. Hougen, B.A. Hopkins and T.W. Smith, Am. J. Physiol.234, C59 (1978).

    Article  CAS  PubMed  Google Scholar 

  26. H. Porzig, J. membr. Biol.31, 317 (1977).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Merker, H.J., Günther, T. The influence of insulin, cAMP and the calcium ionophore X 537 A on the growth of the cartilage anlagen of limb buds in vitro. Experientia 35, 1307–1308 (1979). https://doi.org/10.1007/BF01963975

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01963975

Keywords

Navigation