Summary
Limb buds of 11-day-old mouse embryos were cultured for 6 days with insulin, dibutyryl cAMP and X 537 A. The cartilage anlage was reduced by insulin and enlarged by dibutyryl cAMP and X 537 A. The effects are due to changes in the amount of intercellular substance.
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References
D.L. Friedman, Physiol. Rev.56, 652 (1976).
I.H. Pastan, G.S. Johnson and W.B. Anderson, A. Rev. Biochem.44, 491 (1975).
D.L. Friedman, R.A. Johnson and C.E. Zeilig, Adv. Cycl. Nucl. Res.7, 69 (1976).
H.D. Peters, K. Karzel, D. Padberg, P.S. Schönhöfer and V. Dinnendahl, Pol. J. Pharmac. Pharm.26, 41 (1974).
M. Shinmei, P. Ghosh and T.K.F. Taylor, Biochim. biophys. Acta,437, 94 (1974).
C.W. Castor, J. lab. clin. Med.83, 46 (1974).
M. Tomida, H. Koyama and T. Ono, Biochem. J.162, 539 (1977).
G. Manner and M. Kuleba, Connect. Tissue Res.2, 167 (1974).
M.B. Aydelotte and D. Kochhar, Devl Biol.28, 191 (1972).
D. Neubert, H.-J. Merker and S. Tapken, Naunyn-Schmiedebergs Arch. Pharmac.286, 251 (1974).
B.C. Pressman, Fed. Proc.32, 1698 (1973).
A.B. Borle and R. Studer, J. membr. Biol.38, 51 (1978).
H. Rasmussen and D.B.P. Goodman, Physiol. Rev.57, 421 (1977).
L.S. Bradham, D.A. Holt and M. Sims, Biochim. biophys. Acta201, 250 (1970).
C.O. Brostrom, Y.-C. Huang, B.M. Breckenridge and D.J. Wolff, Proc. nat. Acad. Sci.72, 64 (1975).
W.Y. Cheung, L.S. Bradham, T.J. Lynch, M.Y. Lin and E.A. Tallant, Biochem. biophys. Res. Commun.66, 1055 (1975).
S. Kakiuchi, R. Yamazaki, Y. Teshima and K. Uenishi, Proc. nat. Acad. Sci.70, 3526 (1973).
Th. Günther and R. Averdunk, J. clin. Chem. clin. Biochem.14, 365 (1976).
N. Friedmann and C.R. Park, Proc. nat. Acad. Sci.61, 504 (1968).
R. Dulbecco and J. Elkington, Proc. nat. Acad. Sci.72, 1584 (1975).
M.H. Gail, Ch.W. Boone and C.S. Thompson, Exp. Cell Res.79, 386 (1973).
S.D. Balk, J.F. Whitfield, T. Youdale and A.C. Braun, Proc. nat. Acad. Sci.70, 675 (1973).
J.W. Craig, T.W. Rall and J. Larner, Biochim. biophys. Acta177, 213 (1969).
W.A. Gavryck, R.D. Moore and R.C. Thompson, J. Physiol.252, 43 (1975).
T.J. Hougen, B.A. Hopkins and T.W. Smith, Am. J. Physiol.234, C59 (1978).
H. Porzig, J. membr. Biol.31, 317 (1977).
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Merker, H.J., Günther, T. The influence of insulin, cAMP and the calcium ionophore X 537 A on the growth of the cartilage anlagen of limb buds in vitro. Experientia 35, 1307–1308 (1979). https://doi.org/10.1007/BF01963975
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DOI: https://doi.org/10.1007/BF01963975