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Prostaglandin-like substances inPropionibacterium acnes. III. Differential contractile effects on smooth muscle layers of the human utero-tubal junction

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Summary

The biological activity of a lipid fraction extracted fromP. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. The bioassay experiments support the concept that prostaglandin-like substances (PLS) occur inP. acnes. However, in the bioassay system used, the effect of PLS was different from that of PGF2α and PGI2 but similar, although not identical, to that of arachidonic acid and PGE2.

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Authors and Affiliations

  1. Department of Dermatology, University of Trondheim, Trondheim, Norway

    L. Hellgren, B. Lindblom, J. Vincent & L. Wilhelmsson

  2. Departments of Dermatology, Obstetrics and Gynecology, Sahlgren's Hospital, S-40033, Göteborg 33, Sweden

    L. Hellgren, B. Lindblom, J. Vincent & L. Wilhelmsson

  3. Department of Structural Chemistry, Faculty of Medicine, University of Göteborg, S-40033, Göteborg 33, Sweden

    L. Hellgren, B. Lindblom, J. Vincent & L. Wilhelmsson

Authors
  1. L. Hellgren
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  2. B. Lindblom
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  3. J. Vincent
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  4. L. Wilhelmsson
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Additional information

Acknowledgments. We are greatly indebted to Ass. Prof. Krister Gréen and Prof. Nils Wiqvist for critical review of the manuscript.

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Hellgren, L., Lindblom, B., Vincent, J. et al. Prostaglandin-like substances inPropionibacterium acnes. III. Differential contractile effects on smooth muscle layers of the human utero-tubal junction. Experientia 35, 1298–1299 (1979). https://doi.org/10.1007/BF01963969

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  • DOI: https://doi.org/10.1007/BF01963969

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