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Review ofCitrobacter bacteremia in cancer patients over a sixteen-year period

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Abstract

A review was conducted of 65 episodes ofCitrobacter bacteremia in cancer patients during a 16-year period. Cases of polymicrobial bacteremia were excluded from this analysis. The infection occurred most commonly in patients with acute leukemia. Most patients acquired the infection in the hospital, and 57 % had received antibiotic therapy during the preceding ten days. Fever occurred in 98 % of cases and shock in 17 %. Thirty-eight percent of patients had concomitant pneumonia. Patients with shock, pneumonia or hemorrhage had a substantially poorer prognosis. The response rate was 72 % for patients who received appropriate antibiotics. Patients who continued to have positive blood culture results while receiving appropriate antibiotic therapy had a poor prognosis. Beta-lactam antibiotics were more effective than aminoglycosides.

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Authors and Affiliations

  1. Division of Medicine, The University of Crete, Heraklion Crete, Greece

    G. Samonis

  2. Section of Infectious Diseases, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 47, 77030, Houston, Texas, USA

    E. Anaissie, L. Elting & G. P. Bodey

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  1. G. Samonis
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  2. E. Anaissie
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  3. L. Elting
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  4. G. P. Bodey
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Samonis, G., Anaissie, E., Elting, L. et al. Review ofCitrobacter bacteremia in cancer patients over a sixteen-year period. Eur. J. Clin. Microbiol. Infect. Dis. 10, 479–485 (1991). https://doi.org/10.1007/BF01963933

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