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Preparation of lyophilized heat-treated cryoprecipitates from a small pool of plasma obtained by apheresis

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Abstract

A method was developed for the batch-wise production of small-pool lyophilized heat-treated cryoprecipitates in a regional Blood Bank. Ten vials of final product were derived from twenty 600 g apheresis plasma donations. We found 384 IU of factor VIII per vial and a specific activity of 0.20 IU per mg total protein. Production recovery was 340 IU of factor VIII per kg plasma. The method was easy to perform and gave a product of good quality.

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Authors and Affiliations

  1. Central Pharmacy of the Hospitals of The Hague, P.O. Box 43100, 2504, AC The Hague, The Netherlands

    D. P. Allersma

  2. Red Cross Blood Bank, Leyweg 275, 2545, CJ The Hague, The Netherlands

    E. Roeffen & J. A. Van der Does

  3. Department of Haematology, University Hospital Leiden, P.O. Box 9600, 2300, RA Leiden, The Netherlands

    E. Briët

Authors
  1. D. P. Allersma
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  2. E. Roeffen
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  3. J. A. Van der Does
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  4. E. Briët
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Allersma, D.P., Roeffen, E., Van der Does, J.A. et al. Preparation of lyophilized heat-treated cryoprecipitates from a small pool of plasma obtained by apheresis. Pharmaceutisch Weekblad Scientific Edition 13, 18–23 (1991). https://doi.org/10.1007/BF01963879

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  • DOI: https://doi.org/10.1007/BF01963879

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