Advertisement

Effect of varying pH on the susceptibility ofCampylobacter pylori to antimicrobial agents

  • M. L. Grayson
  • G. M. Eliopoulos
  • M. J. Ferraro
  • R. C. MoelleringJr.
Notes

Abstract

The susceptibility of 22 clinical isolates ofCampylobacter pylori to eight antimicrobial agents was studied under varying pH conditions. Macrolides (erythromycin, dirythromycin), clindamycin and to a lesser extent quinolones lost efficacy at lowered pH. The activity of ampicillin and metronidazole remained relatively stable throughout the pH range tested. The effect of pH an antimicrobial efficacy may warrant consideration when selecting an antibiotic to clearCampylobacter pylori in vivo, since the pH of the gastric submucous environment is not known for certain.

Keywords

Internal Medicine Ampicillin Erythromycin Antimicrobial Agent Metronidazole 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Marshall, B. J., Warren, J. R.: Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1984, i: 1311–1315.CrossRefGoogle Scholar
  2. 2.
    Morris, A., Nicholson, G.: Ingestion ofCampylobacter pyloridis causes gastritis and raised fasting pH. American Journal of Gastroenterology 1987, 82: 192–199.PubMedGoogle Scholar
  3. 3.
    Drumm, B., Sherman, P., Cutz, E., Karmal, M.: Association ofCampylobacter pylori on the gastric mucosa with antral gastritis in children. New England Journal of Medicine 1987, 316: 1557–1561.PubMedGoogle Scholar
  4. 4.
    Marshall, B. J., Goodwin, C. S., Warren, J. R., Murray, R., Blincow, E. D., Blackbourn, S. J., Phillips, M., Waters, T. E., Sanderson, C. R.: Prospective double-blind trial of duodenal ulcer relapse after eradication ofCampylobacter pylori. Lancet 1988, ii: 1437–1442.CrossRefGoogle Scholar
  5. 5.
    Langenberg, M. L., Tutgat, G. N., Schipper, M. E., Rietra, P. J., Zanen, H. C.:Campylobacter-like organisms in the stomach of patients and healthy individuals. Lancet 1984, i: 1348–1349.CrossRefGoogle Scholar
  6. 6.
    Shungu, D. L., Nalin, D. R., Gilman, R. H., Gadebusch, H. H., Cerami, A. T., Gill, C., Weissberger, B.: Comparative susceptibilities ofCampylobacter pylori to nor-floxacillin and other agents. Antimicrobial Agents and Chemotherapy 1987, 31: 949–950.PubMedGoogle Scholar
  7. 7.
    Hardy, D. J., Hanson, C. W., Hensey, D. M., Beyer, J. M., Fernandes, P. B.: Susceptibility ofCampylobacter pylori to macrolides and fluoroquinolones. Journal of Antimicrobial Chemotherapy 1988, 22: 631–636.PubMedGoogle Scholar
  8. 8.
    Williams, S. E., Turnberg, L. A.: Demonstration of pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a “mucus-bicarbinate” barrier. Gut 1981, 22: 94–96.PubMedGoogle Scholar
  9. 9.
    Stone, J. W., Wise, R., Donovan, I. A., Gearty, J.: Failure of ciprofloxacin to eradicateCampylobacter pylori from the stomach. Journal of Antimicrobial Chemotherapy 1988, 22: 92–93.PubMedGoogle Scholar
  10. 10.
    Glupczynski, Y., Labbe, M., Burette, A., Delmee, M., Avesani, V., Bruck, C.: Treatment failure of ofloxacin inCampylobacter pylori infection. Lancet 1987, i: 1096.CrossRefGoogle Scholar
  11. 11.
    McNulty, C. A., Gearty, J. C., Crump, B., Davis, M., Donovan, I. A., Melikian, V., Lister, D. M., Wise, R.:Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. British Medical Journal 1985, 293: 645–649.Google Scholar
  12. 12.
    Oderba, G., Holton, J., Altare, F., Vaira, D., Ainley, C., Ansaldi, N.: Amoxycillin plus tinidazole forCampylobacter pylori gastritis in children: Assessment by serum IgG antibody, pepsinogen 1, and gastrin levels. Lancet 1989, i: 690–692.CrossRefGoogle Scholar
  13. 13.
    Börsch, G., Mai, U., Opferkuch, W.: Short- and medium-term results of oral triple therapy to eradicateCampylobacter pylori. Gastroenterology 1989, 96: A53.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1989

Authors and Affiliations

  • M. L. Grayson
    • 1
    • 3
  • G. M. Eliopoulos
    • 1
    • 3
  • M. J. Ferraro
    • 2
    • 3
  • R. C. MoelleringJr.
    • 1
    • 3
  1. 1.Department of MedicineNew England Deaconess HospitalBostonUSA
  2. 2.Department of Medicine and MicrobiologyMassachusetts General HospitalBostonUSA
  3. 3.Harvard Medical SchoolBostonUSA

Personalised recommendations