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Studies on the emergence of resistance to lomefloxacin in vitro

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  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

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Abstract

The emergence of resistance to lomefloxacin, norfloxacin and ciprofloxacin was investigated in nalidixic acid sensitive and resistant urinary isolates by continuous turbidimetry. A decline in susceptibility was observed after a single exposure to each of the drugs, and further increments of resistance occurred during three sequential passages. Variants resistant to one quinolone were cross-resistant to the others. The level of resistance selected by norfloxacin in three of the five test strains was greater than that observed with lomefloxacin or ciprofloxacin. In experiments in a model of the treatment of bacterial cystitis, concentrations of lomefloxacin well within those readily achievable in urine suppressed growth of nalidixic acid sensitive and resistant strains for more than 20 h without causing any decline in susceptibility of surviving bacteria.

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Authors and Affiliations

  1. Department of Urology, Gifu University School of Medicine, 500, Gifu-shi, Japan

    M. Kanematsu

  2. Department of Microbiology and PHLS Laboratory, University Hospital, Queen's Medical Centre, NG7 2UH, Nottingham, UK

    D. Greenwood

Authors
  1. M. Kanematsu
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  2. D. Greenwood
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Kanematsu, M., Greenwood, D. Studies on the emergence of resistance to lomefloxacin in vitro. Eur. J. Clin. Microbiol. Infect. Dis. 8, 741–745 (1989). https://doi.org/10.1007/BF01963766

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  • DOI: https://doi.org/10.1007/BF01963766

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