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Dinemorphan N-demethylation by mouse liver microsomes

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Summary

Dinemorphan, an antitussive drug, is N-demethylated in vitro by mouse liver microsomes with biphasic kinetics showing two apparent Km and Vmax. Moreover, dinemorphan N-demethylation is inhibited by CO, SKF-525A, metyrapone and it is specifically catalyzed by a phenobarbital-inducible form of cytochrome P-450.

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Authors and Affiliations

  1. Istituto di Mutagenesi e Differenziamento CNR, Via Svezia 10, I-56100, Pisa, (Italy)

    P. G. Gervasi, D. Benetti, L. Citti, M. Del Monte & G. Turchi

  2. Div. Centro Ricerche, Istituto Gentili SpA, Via Mazzini 112, I-56100, Pisa, (Italy)

    P. G. Gervasi, D. Benetti, L. Citti, M. Del Monte & G. Turchi

Authors
  1. P. G. Gervasi
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  2. D. Benetti
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  3. L. Citti
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  4. M. Del Monte
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  5. G. Turchi
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Additional information

Acknowledgments. We thank Prof. F. Oesch and I.G.C. Robertson for critical reading of the manuscript.

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Gervasi, P.G., Benetti, D., Citti, L. et al. Dinemorphan N-demethylation by mouse liver microsomes. Experientia 40, 180–182 (1984). https://doi.org/10.1007/BF01963588

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  • DOI: https://doi.org/10.1007/BF01963588

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