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Skinned smooth muscle: Time course of force and ATPase activity during contraction cycle

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Summary

The time course of ATPase activity and force has been determined during contraction and relaxation in skinned (hyperpermeable) anterior byssus retractor muscle, ABRM, ofMytilus edulis and compared with corresponding measurements on skinned taenia coli of guinea-pigs. Following a calcium-induced contraction, lowering the [Ca++] to 10−8 M rapidly reduces ATPase activity within 2 min to resting levels while force declines only to about 30–50% of maximal tension within the same time. Thus slow relaxation is due to a ‘catch-like-state’ which is common to different kinds of smooth muscles and can be reduced with cAMP in ABRM and by Pi in taenia coli.

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Authors and Affiliations

  1. Department of Physiology II, University of Heidelberg, Im Neuenheimer Feld 326, D-6900, Heidelberg, (Federal Republic of Germany)

    K. Güth, M. Gagelmann & J. C. Rüegg

Authors
  1. K. Güth
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  2. M. Gagelmann
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  3. J. C. Rüegg
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Additional information

The support by the Deutsche Forschungsgemeinschaft and the excellent technical assistance of Mrs K. Winnikes are gratefully acknowledged.

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Güth, K., Gagelmann, M. & Rüegg, J.C. Skinned smooth muscle: Time course of force and ATPase activity during contraction cycle. Experientia 40, 174–176 (1984). https://doi.org/10.1007/BF01963585

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  • DOI: https://doi.org/10.1007/BF01963585

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