Experientia

, Volume 35, Issue 9, pp 1230–1232 | Cite as

Peritoneal macrophages from adjuvant arthritic rats enhance tumour cell growth in vitro

  • L. Binderup
  • E. Bramm
  • E. Arrigoni-Martelli
Specialia

Summary

Peritoneal macrophages from rats with adjuvant arthritis enhance the incorporation of3H-thymidine in 2 tumour cell lines in vitro. Maximal enhancement is found during the development of the secondary lesions, and it is suggested that the immunologic commitment of the macrophages could interfere with their regulation of tumour cell proliferation in vivo.

Keywords

Tumour Cell Arthritis Cell Proliferation Cell Growth Tumour Cell Line 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 2.
    M.H. Levy and E.F. Wheelock, Adv. Cancer Res.20, 131 (1974).Google Scholar
  2. 3.
    J.B. Hibbs, J. Retiuloendoth. Soc.20, 223 (1976).Google Scholar
  3. 4.
    R. Strauss, L. Mills and P. Navin, Ann. N.Y. Acad. Sci.276, 520 (1976).Google Scholar
  4. 5.
    S.E. Salmon and A.W. Hamburger, Lancet2, 1289 (1978).Google Scholar
  5. 6.
    B.H. Waksman, C.M. Pearson and J.T. Sharp, J. Immun.85, 403 (1960).Google Scholar
  6. 7.
    T. Yoshida, Meth. Cancer Res.1, 97 (1971).Google Scholar
  7. 8.
    R. Keller, in: Immunobiology of the Macrophage, p. 487. Ed. D.S. Nelson. Academic Press, New York 1976.Google Scholar
  8. 9.
    C.F. Nathan and N.D. Terry, J. exp. Med.142, 887 (1975).Google Scholar
  9. 10.
    C.M. Pearson and F.D. Wood, Am. J. Path.42, 73 (1963).Google Scholar
  10. 11.
    B.B. Newbould, Ann. rheum. Dis.23, 392 (1964).Google Scholar
  11. 12.
    J.B. Hibbs, R.R. Taintor, H.A. Chapman and J.B. Weinberg, Science197, 279 (1977).Google Scholar
  12. 13.
    K.C. Lee and D. Berry, J. Immun.118, 1530 (1977).Google Scholar
  13. 14.
    V.I. Kaledin, Y.N. Kurunov and I.A. Serova, J. nat. Cancer Inst.58 1271 (1977).Google Scholar
  14. 15.
    M.S. Meltzer and J.L. Leonard, J. nat. Cancer Inst.50, 209 (1973).Google Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • L. Binderup
    • 1
  • E. Bramm
    • 1
  • E. Arrigoni-Martelli
    • 1
  1. 1.Department of PharmacologyLeo Pharmaceutical ProductsBallerupDenmark

Personalised recommendations