, Volume 35, Issue 9, pp 1213–1215 | Cite as

Protein synthesis inhibition induced by dimethylnitrosamine and diethylnitrosamine on isolated rat hepatocytes

  • Elisabetta Mattei
  • Andrea Delpino
  • U. Ferrini


Time- and dose-dependent protein synthesis inhibition takes place following exposure to high doses of dimethylnitrosamine (DMN) or diethylnitrosamine (DENA) in isolated rat hepatocytes. The ability of DENA to depress protein synthesis is 5-fold higher than that of DMN. Cells inhibited by 60 min exposure to DMN or DENA, and then incubated in a nitrosamine-free medium, regain their initial rate of protein synthesis. This recovery is faster and more complete for DENA-treated cells.


Protein Synthesis Initial Rate DENA Synthesis Inhibition Protein Synthesis Inhibition 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • Elisabetta Mattei
    • 1
  • Andrea Delpino
    • 1
  • U. Ferrini
    • 1
  1. 1.Biophysical LaboratoryInstitute Regina Elena for Cancer ResearchRomeItaly

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