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Comparison of the biological effects of anemia inducing and polycythemia inducing Friend virus complex

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Summary

The comparison of the biological effects of FVP and FVA showed that leukemogenesis appears to be delayed in FVA infected mice as compared to FVP infected animals after injection of comparable quantities of virus as measured in spleen focus forming units. In addition, no CFU-EI, characteristic for FVP induced leukemia, were found in leukemic spleen or bone marrow of FVA infected mice. Since it was possible to distinguish both viruses by their different host ranges, which are helper virus determined, it is suggested that the observed differences, especially the lack of CFU-EI in FVA infected mice, might be due to differences in the helper virus component of the FV complex.

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Author notes

  1. G. Steinheider

    Present address: Institut für Molekularbiologie und Biochemie der Freien Universität Berlin, Arnimallee 22, D-1000, Berlin 33, Germany

Authors and Affiliations

  1. Department of Clinical Physiology, University of Ulm, D-7900, Ulm a.d. Donau, Federal Republic of Germany

    G. Steinheider, H. J. Seidel, L. Kreja & M. Grünefeld

Authors
  1. G. Steinheider
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  2. H. J. Seidel
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  3. L. Kreja
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  4. M. Grünefeld
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Additional information

Supported by the Deutsche Forschungsgemeinschaft (SFB 112 Zellsystemphysiologie).

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Steinheider, G., Seidel, H.J., Kreja, L. et al. Comparison of the biological effects of anemia inducing and polycythemia inducing Friend virus complex. Experientia 35, 1173–1175 (1979). https://doi.org/10.1007/BF01963269

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  • DOI: https://doi.org/10.1007/BF01963269

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