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Inhibition of the NADP-linked glutamate dehydrogenase fromTrypanosoma cruzi by silver nitrate

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Summary

The purified NADP-linked glutamate dehydrogenase fromTrypanosoma cruzi was strongly inhibited by silver nitrate. The inhibition was reversed by reduced glutathione, and was modified by the presence of the substrates during preincubation of the enzyme with the inhibitor.

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References

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Authors and Affiliations

  1. CEFOBI, Centro de Estudios Fotosintéticos y Bioquímicos (CONICET, Fundación Miguel Lillo, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina

    Silvia M. Juan, Elsa L. Segura & J. J. Cazzulo

  2. Instituto Nacional de Diagnóstico e Investigación de la Enfermedad de Chagas ‘Dr Mario Fatala Chabén’, Secretaría de Estado de Salud Pública, Paseo Colón 568, Buenos Aires, Argentina

    Silvia M. Juan, Elsa L. Segura & J. J. Cazzulo

Authors
  1. Silvia M. Juan
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  2. Elsa L. Segura
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  3. J. J. Cazzulo
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Additional information

This work was supported by grants from the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the Secretaría de Estado de Ciencia y Technología de la República Argentina. JJC is a member of the Carrera del Investigador Científico, and SMJ a Research Fellow, of the former Institution.

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Juan, S.M., Segura, E.L. & Cazzulo, J.J. Inhibition of the NADP-linked glutamate dehydrogenase fromTrypanosoma cruzi by silver nitrate. Experientia 35, 1139–1140 (1979). https://doi.org/10.1007/BF01963246

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  • DOI: https://doi.org/10.1007/BF01963246

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