Advertisement

Pharmaceutisch Weekblad

, Volume 6, Issue 3, pp 101–104 | Cite as

Formulation of a stable vidarabine phosphate injection

  • M. S. L. Kwee
  • L. M. L. Stolk
Original Articles

Abstract

An injection fluid with vidarabine phosphate (37.5 mg/ml, pH 7.4) was formulated. After steam sterilization for 20 min at 120°C a 6.1% degradation was observed. No significant (p>0.05) degradation could be observed after heating in steam for 30 min at 100°C and after storage for four months at 4°C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content after a three years' storage period at 4°C could be predicted.

Keywords

Public Health Phosphate Internal Medicine Elevated Temperature Degradation Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Lepage GA, Naik SR, Katakkar SB, Khalig A. 9-beta-d-arabinofuranosyladenine 5′-phosphate metabolism and excretion in humans. Cancer Res 1975;35:3036–40.Google Scholar
  2. 2.
    Preiksaitis JK, Lank B, Ng PK, Brox L, LePage GA, Tyrell DL. Effect of Liver Disease on Pharmacokinetics and toxicity of 9-β-d-Arabinofuranosyladenine-5′-Phosphate. J Infect Dis 1981;144:358–64.Google Scholar
  3. 3.
    Whitley RJ, Tucker BC, Kinkel AW, et al. Pharmacology, Tolerance and Antiviral Activity of Vidarabine Monophosphate in Humans. Antimicrob Agents Chemother 1980;18:709–15.Google Scholar
  4. 4.
    Weller IVD, Bassendine MF, Craxi A, et al. Successful treatment of HBs and HBeAg positive chronic liver disease: prolonged inhibition of viral replication by highly soluble adenine arabinoside 5′-monophospate (ARA-AMP). Gut 1982;23:717–23.Google Scholar
  5. 5.
    Stolk LML, Huisman W, Nordemann HD, Vyth A. Formulation of a stable vidarabine infusion fluid. Pharm Weekbl [Sci] 1983;5:57–60.Google Scholar
  6. 6.
    Weast RC, Selby SM, eds. Handbook of Chemistry and Physics, 47th ed. Cleveland, Ohio: Chemical Rubber Co., 1966:A-244.Google Scholar
  7. 7.
    Grimm W, Schepky G. Stabilitätsprüfung in der Pharmazie. Aulendorf: Editio Cantor, 1980.Google Scholar

Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1984

Authors and Affiliations

  • M. S. L. Kwee
    • 1
  • L. M. L. Stolk
    • 2
  1. 1.Faculty of Pharmacy, Division of PharmacotherapyUniversity of AmsterdamTV AmsterdamThe Netherlands
  2. 2.Clinical Pharmacy DepartmentUniversity Hospital of AmsterdamAZ AmsterdamThe Netherlands

Personalised recommendations