Formulation of a stable vidarabine phosphate injection
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An injection fluid with vidarabine phosphate (37.5 mg/ml, pH 7.4) was formulated. After steam sterilization for 20 min at 120°C a 6.1% degradation was observed. No significant (p>0.05) degradation could be observed after heating in steam for 30 min at 100°C and after storage for four months at 4°C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content after a three years' storage period at 4°C could be predicted.
KeywordsPublic Health Phosphate Internal Medicine Elevated Temperature Degradation Rate
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