, Volume 35, Issue 11, pp 1531–1532 | Cite as

Endocrine control of lysosomal alterations in rat liver during the perinatal period

  • D. Bal
  • R. Vaillant


Within hours of birth, some physical properties of liver lysosomes are modified. These alterations, which may be related to the autophagic vacuoles formation known to occur during this period, were inhibited by insulin administration. Glucagon, a potent inducer of autophagy in adult rat liver, did not anticipate this process in fetal liver. Our results suggest that the decrease of plasma insulin immediately after birth is a important factor in the development of hepatic autophagy.


Glucagon Plasma Insulin Fetal Liver Potent Inducer Perinatal Period 
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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • D. Bal
    • 1
    • 2
  • R. Vaillant
    • 1
    • 2
  1. 1.Lab. de Physiologie comparéeUniversité Pierre-et-Marie-CurieParis
  2. 2.Lab. d'EndocrinologieMont Saint-Aignan(France)

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