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Pharmaceutisch Weekblad

, Volume 14, Issue 3, pp 61–77 | Cite as

Platinum antitumour agents: A review of (bio)analysis

  • T. J. M. Hodes
  • W. J. M. Underberg
  • G. Los
  • J. H. Beijnen
Reviews

Abstract

This paper summarizes analytical techniques in order to get a clear picture of the ins and outs of the (bio)analysis of platinum-containing compounds. The antitumour agent cisplatin has become an indispensable drug for the cure of a variety of cancer diseases. Since its introduc-tion in the early seventies, about 2,000 related platinum complexes were designed to devoid the dose-limiting nephrotoxicity. Some of them were introduced for clinical trial, such as carboplatin and iproplatin. To investigate the mechanism of action and pharmaco-kinetic behaviour, several interesting assays for total and specific platinum determination in biological matrices have been developed, each with its own possibilities and limitations.

Keywords

Chemistry, analytical Chromatography Cisplatin Electrochemistry Platinum compounds Radiochemistry Spectrometry 

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1992

Authors and Affiliations

  • T. J. M. Hodes
    • 1
  • W. J. M. Underberg
    • 1
  • G. Los
    • 2
  • J. H. Beijnen
    • 3
  1. 1.Department of Pharmaceutical Analysis, Faculty of PharmacyState University of UtrechtTB Utrechtthe Netherlands
  2. 2.Department of Medicine, Division of Haematology/OncologyUniversity of California/San DiegoLa JollaUSA
  3. 3.Slotervaart Hospital/The Netherlands Cancer InstituteEC Amsterdamthe Netherlands

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