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Pharmaceutisch Weekblad

, Volume 10, Issue 2, pp 86–89 | Cite as

Pharmacokinetics of methotrexate in continuous ambulatory peritoneal dialysis

  • R. Janknegt
  • M. J. Nube
  • H. M. Van Den Hoogenband
  • H. G. J. Oldenhof
  • A. Steenhoek
  • T. B. Vree¶
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Abstract

The pharmacokinetics of methotrexate and its 7-hydroxy metabolite were studied in a patient undergoing continuous ambulatory peritoneal dialysis. A biphasic plasma-disappearance pattern of methotrexate was observed, with half-lives of 3.5 and 29 hours. The 7-hydroxy metabolite accumulated and showed a very slow rate of elimination, with an estimated final elimination half-life of over 120 hours. The mean peritoneal clearance rate of methotrexate was 0.13 l/h (range 0.05–0.20 l/h), dwell times significantly influenced the clearance rate. Strict monitoring of the methotrexate level, even after low doses, is necessary in continuous ambulatory peritoneal dialysis patients, to prevent serious bone marrow toxicity.

Keywords

Metabolism Methotrexate Peritoneal dialysis, continuous ambulatory 

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References

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Copyright information

© Royal Dutch Association for Advancement of Pharmacy 1988

Authors and Affiliations

  • R. Janknegt
    • 1
  • M. J. Nube
    • 2
  • H. M. Van Den Hoogenband
    • 3
  • H. G. J. Oldenhof
    • 1
  • A. Steenhoek
    • 1
  • T. B. Vree¶
    • 4
  1. 1.Department of Clinical PharmacyMedisch Centrum AlkmaarHA Alkmaarthe Netherlands
  2. 2.Department of HaemodialysisMedisch Centrum Alkmaarthe Netherlands
  3. 3.Department of DermatologyMedisch Centrum Alkmaarthe Netherlands
  4. 4.Department of Clinical PharmacySt. Radboud HospitalHB Nijmegenthe Netherlands

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