International Urogynecology Journal

, Volume 6, Issue 2, pp 63–67 | Cite as

Oxybutynin and bladder training in the management of female urinary urge incontinence: A randomized study

  • M. Colombo
  • G. Zanetta
  • S. Scalambrino
  • R. Milani
Original Article


A randomized trial of 81 women with detrusor instability, low-compliance or sensory bladder was undertaken to compare the effects of 6 weeks' treatment with oxybutynin (5 mg t.i.d.) or bladder training for urge incontinence. Cystometry was repeated after treatment. Ten per cent of the 42 patients on oxybutynin discontinued the therapy; the cure rate decreased from 74% to 42% during the 6-month period following the treatment (from 93% to 57% in case of detrusor instability). The cure rate of bladder training remained quite high, being reduced only from 73% to 70% (from 81% to 75% in the case of sensory bladder). Twelve of the 13 patients with late relapse of incontinence were on oxybutynin. It was concluded that oxybutynin was not well tolerated and gave only early good results. Bladder training was well accepted and provided persistent results; it may be suggested as the first-line treatment for urge incontinence.


Bladder training Cystometry Detrusor instability Drugs Motor urge incontinence Sensory urge incontinence 


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Copyright information

© The International Urogynecology Journal 1995

Authors and Affiliations

  • M. Colombo
    • 1
  • G. Zanetta
    • 1
  • S. Scalambrino
    • 1
  • R. Milani
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of Milan, San Gerardo HospitalMonzaItaly

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