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In vitro activity of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine againstChlamydia trachomatis SA2f in McCoy cell culture

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Abstract

Chequerboard titrations of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine were performed againstChlamydia trachomatis (strain SA2f) using McCoy cell monolayers in vials. The experiments were continued for ten passages each. The mean fractional inhibitory concentration index for each combination was calculated. Results demonstrated synergistic activity between sulphamethoxazole and trimethoprim, and between sulfadoxine and pyrimethamine.

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Authors and Affiliations

  1. Department of Clinical Microbiology, University College Hospital, Grafton Way, WC1E 6AU, London, UK

    G. Mumtaz, G. L. Ridgway & D. Felmingham

Authors
  1. G. Mumtaz
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  2. G. L. Ridgway
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  3. D. Felmingham
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Mumtaz, G., Ridgway, G.L. & Felmingham, D. In vitro activity of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine againstChlamydia trachomatis SA2f in McCoy cell culture. Eur. J. Clin. Microbiol. Infect. Dis. 7, 415–417 (1988). https://doi.org/10.1007/BF01962352

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  • DOI: https://doi.org/10.1007/BF01962352

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