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Antagonism of the direct fungicidal action of miconazole by miconazole fungistasis

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Abstract

A weakly fungistatic concentration of miconazole in lag phase yeast cultures ofCandida albicans antagonized development of phenotypic susceptibility to the direct fungicidal action of high-level (i.e. >10−5 M) miconazole. After development in the absence of drug, maintenance of susceptibility upon continued incubation was also antagonized by low levels of miconazole. This auto-antagonistic effect has important clinical implications.

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Authors and Affiliations

  1. General Medical Research Service, Veterans Administration Medical Center, 54th Street and 48th Avenue South, 55417, Minneapolis, Minnesota, USA

    W. H. Beggs & I. R. LaSota

  2. Medicine Service, Veterans Administration Medical Center, 54th Street and 48th Avenue South, 55417, Minneapolis, Minnesota, USA

    C. E. Hughes

Authors
  1. W. H. Beggs
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  2. I. R. LaSota
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  3. C. E. Hughes
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Beggs, W.H., LaSota, I.R. & Hughes, C.E. Antagonism of the direct fungicidal action of miconazole by miconazole fungistasis. Eur. J. Clin. Microbiol. Infect. Dis. 7, 413–414 (1988). https://doi.org/10.1007/BF01962351

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  • DOI: https://doi.org/10.1007/BF01962351

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