Abstract
Pefloxacin, which has been shown to have a high in vitro activity againstSalmonella spp., was compared to cotrimoxazole in the treatment of typhoid fever in adults. In a prospective, randomized trial, 42 patients with bacteriologically documented typhoid fever received either 400 mg pefloxacin b.i.d. or 160/800 mg cotrimoxazole b.i.d. Duration of treatment was 14 days in both groups. All patients were cured without experiencing a relapse or becoming a salmonella carrier. Apyrexia and resolution of digestive and neurological symptoms were obtained in a significantly shorter time with pefloxacin than with cotrimoxazole. Pefloxacin was well tolerated and more effective than cotrimoxazole in the treatment of typhoid fever.
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Hajji, M., Mdaghri, N., Benbachir, M. et al. Prospective randomized comparative trial of pefloxacin versus cotrimoxazole in the treatment of typhoid fever in adults. Eur. J. Clin. Microbiol. Infect. Dis. 7, 361–363 (1988). https://doi.org/10.1007/BF01962337
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DOI: https://doi.org/10.1007/BF01962337