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Delta and non-A, non-B hepatitis viruses

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Abstract

A review is given on the current knowledge of the hepatitis delta virus (HDV), the only hepatotropic non-A non-B (NANB) virus characterized, although the infection it causes requires infection with hepatitis B virus (HBV). Studies in chimpanzees have provided the most data now available on the putative NANB agents. Histologic and electron microscopic changes occurring in HDV and NANB hepatitis have been shown to be comparable, and some biologic, epidemiologic and clinical features are similar. However, the lack of cross-protection between NANB and HDV hepatitis in cross-challange transmission experiments and the lack of hybridization between HDV-RNA and nucleic acids from NANB material indicate that HDV and the putative NANB agents are minimally, if at all, related.

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  1. Division of Gastroenterology, San Giovanni Battista “Molinette” Hospital, Corso Bramante 88, 10126, Torino, Italy

    F. Bonino, M. Baldi & A. Demartini

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  1. F. Bonino
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Bonino, F., Baldi, M. & Demartini, A. Delta and non-A, non-B hepatitis viruses. Eur. J. Clin. Microbiol. Infect. Dis. 7, 327–336 (1988). https://doi.org/10.1007/BF01962332

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