Evaluation of in vitro antifungal activity of LY121019

  • M. Hobbs
  • J. Perfect
  • D. Durack
New Antimicrobial Agents

Abstract

LY121019 is a new semisynthetic lipoeptide antifungal agent with potent in vitro fungicidal activity against multiple clinical strains ofCandida albicans andCandida tropicalis but is 10–100 fold less active againstTorulopsis glabrata andCandida parapsilosis. Its in vitro activity againstCandida albicans andCandida tropicalis is comparable to that of amphotericin B. The in vitro fungicidal activity of this new agent supports further investigations into its use in treatment ofCandida infections.

Keywords

Internal Medicine Amphotericin Antifungal Activity Antifungal Agent Clinical Strain 

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References

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1988

Authors and Affiliations

  • M. Hobbs
    • 1
  • J. Perfect
    • 1
  • D. Durack
    • 1
  1. 1.Division of Infectious DiseasesDuke University Medical CenterDurhamUSA

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