Evaluation of in vitro antifungal activity of LY121019
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LY121019 is a new semisynthetic lipoeptide antifungal agent with potent in vitro fungicidal activity against multiple clinical strains ofCandida albicans andCandida tropicalis but is 10–100 fold less active againstTorulopsis glabrata andCandida parapsilosis. Its in vitro activity againstCandida albicans andCandida tropicalis is comparable to that of amphotericin B. The in vitro fungicidal activity of this new agent supports further investigations into its use in treatment ofCandida infections.
KeywordsInternal Medicine Amphotericin Antifungal Activity Antifungal Agent Clinical Strain
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- 1.Gordee, R.S., Zeckner, D.J., Ellis, L.F., Thakker, A.L., Howard, L.C. In vitro and in vivo anticandida activity and toxicology of LY121019. Journal of Antibiotics 1984, 37: 1054–1065.Google Scholar
- 2.Galgiani, J.N., Stevens, D.A. Antimicrobial susceptibility testing of yeasts: a turbidometric technique independent of inoculum size. Antimicrobial Agents and Chemotherapy 1976, 10: 721–726.Google Scholar
- 3.Eagle, H., Mussellman, A.D. The rate of bactericidal action of penicillin in vitro as a function of its concentration and its paradoxically-reduced activity at high concentrations. Journal of Experimental Medicine 1948, 88: 99–130.Google Scholar