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In vitro activity of temafloxacin, a new difluoro quinolone antimicrobial agent

  • New Antimicrobial Agents
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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

Temafloxacin, a new difluoro quinolone, inhibited the majority ofEnterobacteriaceae at ⩽ 1µg/ml. It was 4–8-fold less active than ciprofloxacin and 2-fold less active than ofloxacin. Cefotaxime and imipenem-resistant isolates such asEnterobacter cloacae, Citrobacter freundii, Pseudomonas aeruginosa, andAcinetobacter spp. were inhibited. Temafloxacin inhibitedNeisseria, Branhamella, andHaemophilus species at < 0.25µg/ml. Methicillin-susceptible and methicillin-resistantStaphylococcus aureus, Staphylococcus epidermidis andClostridium spp. were inhibited at concentrations less or equal to that of ciprofloxacin and ofloxacin.

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References

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, College of Physicians and Surgeons, 630 West 168 Street, 10032, New York, New York, USA

    N. X. Chin, V. M. Figueredo & H. C. Neu

  2. Department of Pharmacology, University of Florence, Florence, Italy

    A. Novelli

Authors
  1. N. X. Chin
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  2. V. M. Figueredo
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  3. A. Novelli
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  4. H. C. Neu
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Chin, N.X., Figueredo, V.M., Novelli, A. et al. In vitro activity of temafloxacin, a new difluoro quinolone antimicrobial agent. Eur. J. Clin. Microbiol. Infect. Dis. 7, 58–63 (1988). https://doi.org/10.1007/BF01962176

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  • DOI: https://doi.org/10.1007/BF01962176

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