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In vitro activity of OPC-17116 compared to other broad-spectrum fluoroquinolones

  • H. S. Sader
  • M. E. Erwin
  • R. N. Jones
New Antimicrobial Agents

Abstract

The in vitro activity of OPC-17116 was compared to that of five similar fluoroquinolones (ciprofloxacin, enoxacin, norfloxacin, ofloxacin and temafloxacin). A total of 700 isolates from recent cases of clinical bacteremia were tested. Fifty additional stock strains with well-characterized resistance mechanisms were also processed. The minimal concentrations inhibiting 90 % of strains (MIC90) ofEnterobacteriaceae species were for OPC-17116 0.015–0.5 µg/ml and for ciprofloxacin 0.015–0.25 µg/ml.Moraxella catarrhalis, Haemophilus influenzae andNeisseria gonorrhoeae were very susceptible to OPC-17116 (MIC90 0.015 µg/ml) thus being fourfold more active than ciprofloxacin. For all β-hemolytic streptococci and pneumococci OPC-17116 MICs were ≤0.5 µg/ml. The most resistant enteric bacilli were among theCitrobacter freundii andProvidencia rettgeri strains (MIC90 0.5 µg/ml).Pseudomonas aeruginosa strains were comparably susceptible to OPC-17116 (MIC90 0.5 µg/ml). Low pH and CO2 incubation had an adverse effect on OPC-17116 MICs, and resistance development was documented among current clinical isolates of staphylococci, pseudomonas and someEnterobacteriaceae.

Keywords

Pseudomonas Aeruginosa Clinical Isolate Fluoroquinolones Ofloxacin Norfloxacin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • H. S. Sader
    • 1
    • 2
  • M. E. Erwin
    • 1
  • R. N. Jones
    • 1
  1. 1.Anti-Infectives Research Center, Department of Pathology, 5232 RCPUniversity of Iowa College of MedicineIowa CityUSA
  2. 2.Disciplina de Doencas Infecciosas e ParasitariasEscola Paulista de MedicinaSao PauloBrazil

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