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Pharmacokinetics of roxithromycin and influence of H2-blockers and antacids on gastrointestinal absorption

  • New Antimicrobial Agents
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Abstract

The pharmacokinetics of roxithromycin (300 mg orally) and the influence of the antacid aluminum magnesium hydroxide and the H2-blocker ranitidine on bioavailability of roxithromycin in ten healthy volunteers were studied. Pharmacokinetics after a single dose of roxithromycin were characterized by high peak serum levels (9.1 ± 2.1 mg/l) and a long elimination half-life (7.2 ± 2.5 h), resulting in a large area under the curve (116.9 ± 32.7 mg h/l). High inter- and intraindividual variations were found for both the absorption time and the elimination half-life. The bioavailability of roxithromycin was not affected by coadministration with antacids or ranitidine.

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Authors and Affiliations

  1. Medical Department, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, 1000, Berlin 45, Germany

    M. Boeckh, G. Höffken & S. Daeschlein

  2. Institute of Radiology, Universitätsklinikum Steglitz, Freie Universität Berlin, Hindenburgdamm 30, 1000, Berlin 45, Germany

    P. Koeppe

  3. Department of Respiratory, Infectious and Immunological Diseases, Zehlendorf Hospital, Am Großen Wannsee 80, 1000, Berlin 39, Germany

    H. Lode

Authors
  1. M. Boeckh
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  2. H. Lode
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  3. G. Höffken
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  4. S. Daeschlein
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  5. P. Koeppe
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Boeckh, M., Lode, H., Höffken, G. et al. Pharmacokinetics of roxithromycin and influence of H2-blockers and antacids on gastrointestinal absorption. Eur. J. Clin. Microbiol. Infect. Dis. 11, 465–468 (1992). https://doi.org/10.1007/BF01961866

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  • DOI: https://doi.org/10.1007/BF01961866

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