Abstract
The activity of decaplanin, a new glycopeptide, was compared to that of vancomycin, teicoplanin and daptomycin. Decaplanin was two- to four-fold less active than vancomycin, teicoplanin and daptomycin againstStaphylococcus aureus andStaphylococcus epidermidis, with an MIC90 of 2 µg/ml for methicillin-susceptible and 4 µg/ml for methicillin-resistant isolates. Decaplanin had activity similar to that of vancomycin againstStreptococcus pyogenes, Streptococcus agalactiae, group C and G streptococci, with an MIC90 of 0.12 µg/ml. It was less active than the other agents against the viridans group streptococci (MIC90 4 µg/ml). The activity of decaplanin against enterococci (MIC90 4 µg/ml) was similar to that of vancomycin.Clostridium spp. were inhibited by 0.5 µg/ml, peptostreptococci and peptococci by 0.25 µg/ml. Decaplanin was active from pH 5.5 to 7.5. Inoculum size had a minimal effect on MICs, and increased concentrations of Ca2+ and Mg2+ and 50 % serum did not alter MICs or MBCs.
Similar content being viewed by others
References
Boyce JM: Methicillin-resistantStaphylococcus aureus: detection, epidemiology, and control measures. Infectious Disease Clinics of North America 1989, 3: 901–904.
Chenoweth C, Schaberg D: The epidemiology of enterococci. European Journal Clinical Microbiology and Infectious Diseases 1990, 9: 80–89.
Blumberg HH, Rimland D, Carroll DJ, Terry P, Wachsmuth IK: Rapid development of ciprofloxacin resistance in methicillin-susceptible and -resistantStaphylococcus aureus. Journal of Infectious Diseases 1991, 63: 1279–1285.
National Committee for Clinical Laboratory Standards: Standard methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Approved standard, M7-A2. NCCLS, Villanova, PA, 1990.
Pearson RD, Steigbigel RT, Davis HT, Chapman SW: Method of reliable determination of minimal lethal antibiotic concentrations. Antimicrobial Agents and Chemotherapy 1980, 18: 699–708.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Neu, H.C., Chin, N.X. & Niu, W.W. In vitro activity of the new glycopeptide decaplanin. Eur. J. Clin. Microbiol. Infect. Dis. 11, 458–462 (1992). https://doi.org/10.1007/BF01961864
Issue Date:
DOI: https://doi.org/10.1007/BF01961864