Prevalence of genital human papillomavirus infections in patients at a sexually transmitted diseases clinic

  • Y. L. Chang
  • C. Y. Lin
  • C. J. Tseng
  • H. S. Cheng
  • H. C. Lin
  • C. C. Pao


The human papillomavirus was detected in cervicovaginal cells by the polymerase chain reaction in 14 of 37 (37.8 %) patients attending a sexually transmitted disease (STD) clinic and in 6 of 43 healthy young women (14.0 %) undergoing routine gynecologic examinations who served as controls. The results indicated that even the more malignant types of human papillomaviruses were not uncommon among the control group, and that the prevalence of human papillomavirus infection was significantly higher in STD clinic patients than in the control group. These findings confirm the suggestion that factors other than human papillomavirus infections may be involved in the pathogenesis of cervical cancer.


Polymerase Chain Reaction Internal Medicine Cervical Cancer Young Woman Transmitted Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    zur Hausen H, Schneider A: The role of papillomaviruses in anogenital cancer. In: Salzman NP, Howley PM (ed): The papovaviridae. Plenum Press, New York, 1987, p. 245–263.Google Scholar
  2. 2.
    Galloway DA, McDougall JK: Human papillomaviruses and carcinomas. Advances in Virus Research 1989, 37: 125–171.PubMedGoogle Scholar
  3. 3.
    Gergely L, Czegledy J, Hernady Z: Human papillomavirus frequency in normal cervical tissue. Lancet 1987, ii: 513.CrossRefGoogle Scholar
  4. 4.
    Bauer HM, Greer CE, Chambers JC, Tashiro CJ, Chimera J, Reingold A, Manos M: Genital human papillomavirus infection in female university students as determined by a PCR-based method. Journal of the American Medical Association 1991, 265: 472–477.CrossRefPubMedGoogle Scholar
  5. 5.
    zur Hausen H: Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers. Cancer Research 1989, 49: 4677–4681.PubMedGoogle Scholar
  6. 6.
    Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Hoguchi R, Horn GJ, Mullis KB, Erlich HA: Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988, 239: 487–491.PubMedGoogle Scholar
  7. 7.
    Pao CC, Lin CY, Maa JS, Lai CH, Wu SY, Soong YK: Detection of human papillomaviruses in cervicovaginal cells using polymerase chain reaction. Journal of Infectious Diseases 1990, 161: 113–115.PubMedGoogle Scholar
  8. 8.
    Pao CC, Lin SS, Lin CY, Maa JS, Lai CH, Hsieh TT: Identification of human papillomavirus in peripheral blood mononuclear cells by DNA amplification method. American Journal of Clinical Pathology 1991, 95: 540–546.PubMedGoogle Scholar
  9. 9.
    Sato S, Okagaki T, Clark BA, Twiggs LB, Fukushima M, Ostrow RS, Faras AJ: Sensitivity of koilocytosis, immunocytochemistry, and electron microscopy as compared to DNA hybridization in detection HPV in cervical and vaginal condyloma. International Journal of Gynecologic Pathology 1987, 5: 297–307.Google Scholar
  10. 10.
    Pao CC, Lai CH, Wu SY, Young KC, Chang PL, Soong YK: Detection of human papillomaviruses in exfoliated cervicovaginal cells by in situ DNA hybridization analysis. Journal of Clinical Microbiology 1989, 27: 168–173.PubMedGoogle Scholar
  11. 11.
    Maniatis T, Fritsch EF, Sambrook J: Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1982, p. 458–459.Google Scholar
  12. 12.
    Schneider A, Hotz M, Gissmann L: Increased prevalence of human papillomaviruses in the lower genital tract of pregnant women. International Journal of Cancer 1987, 40: 198–201.Google Scholar
  13. 13.
    Kiviat NB, Koutsky LA, Paavonen JA, Galloway DA, Critchlow CW, Beckmann AM, McDougall K, Peterson ML, Stevens CE, Lipinski CM, Holmes KK: Prevalence of genital papillomavirus infection among women attending a college student health clinic or a sexually transmitted disease clinic. Journal of Infectious Diseases 1989, 159: 293–302.PubMedGoogle Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • Y. L. Chang
    • 1
  • C. Y. Lin
    • 1
  • C. J. Tseng
    • 2
  • H. S. Cheng
    • 3
  • H. C. Lin
    • 4
  • C. C. Pao
    • 1
  1. 1.Department of BiochemistryChang Gung Medical College and Memorial HospitalTao YuanTaiwan
  2. 2.Department of Obstetrics and GynecologyChang Gung Medical College and Memorial HospitalTao YuanTaiwan
  3. 3.Department of Family MedicineChang Gung Medical College and Memorial HospitalTao YuanTaiwan
  4. 4.Taipei Municipal Venereal Disease Control InstituteTaipeiTaiwan

Personalised recommendations