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Org 4333, a potent, irreversibly binding estrogen agonist

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Abstract

Two synthetic routes to 11β-chloromethylestra-1,3,5(10)-trien-3,17β-diol (Org 4333) are described. In biological tests this compound was found to be a potent irreversibly binding estrogen agonist.

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Authors and Affiliations

  1. Scientific Development Group, Organon, 5340, BH Oss, The Netherlands

    A. J. van den Broek, J. Leemhuis, M. S. de Winter & F. J. Zeelen

Authors
  1. A. J. van den Broek
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  2. J. Leemhuis
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  3. M. S. de Winter
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  4. F. J. Zeelen
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Additional information

In honour of Professor Faber on the occasion of his 25-years' professorate.

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van den Broek, A.J., Leemhuis, J., de Winter, M.S. et al. Org 4333, a potent, irreversibly binding estrogen agonist. Pharmaceutisch Weekblad Scientific Edition 5, 182–183 (1983). https://doi.org/10.1007/BF01961478

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  • DOI: https://doi.org/10.1007/BF01961478

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