Skip to main content
SpringerLink
Log in

Hereditary breast cancer in sweden: a predominance of maternally inherited cases

  • Report
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

The family history of breast cancer was studied in 1975 breast cancer patients of all ages. All the patients were found in an ongoing care program for breast cancer patients in the Stockholm area. One hundred and thirty-three families (6.7%) with hereditary breast cancer, 87 (4.4%) families with hereditary breast- and other cancers, and 14 (0.7%) families with the SBLA syndrome were found. There was no association between familiality and bilateral disease, but familial cases tended to be younger at the time of diagnosis. Determination of the parental origin of the disease gene among the index cases revealed twice as many cases where the disease was maternally transmitted. This might be due to a better prognosis when the predisposing gene is maternally transmitted, and could be explained by parental imprinting or environmental factors influencing the expression of the gene.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Sattin RW, Rubin GL, Webster LA, Huezo CM, Wingo PA, Ory HW, Layde PM: The cancer and steroid hormone study: family history and the risk of breast cancer. JAMA 253: 1908–1913, 1985

    PubMed  Google Scholar 

  2. Ottman R, Pike MC, King M-C, Casagrande JT, Henderson BE: Familial breast cancer in a population-based series. Am J Epidemiol 123: 15–21, 1986

    PubMed  Google Scholar 

  3. Anderson DE: A genetic study of human breast cancer. J Natl Cancer Inst 48: 1029–1034, 1972

    PubMed  Google Scholar 

  4. Anderson DE: Breast cancer in families. Cancer 40: 1855–1860, 1977

    PubMed  Google Scholar 

  5. Anderson DE, Badzioch MD: Risk of familial breast cancer. Cancer 56: 383–387, 1985

    PubMed  Google Scholar 

  6. Anderson DE, Badzioch MD: Bilaterality in familial breast cancer patients. Cancer 56: 2092–2098, 1985

    PubMed  Google Scholar 

  7. Lynch HT, Guirgis H, Brodkey F, Maloney K, Lynch PM, Rankin L, Lynch J: Early age of onset in familial breast cancer. Arch Surg 111: 126–131, 1976

    PubMed  Google Scholar 

  8. Lynch HT, Watson P, Conway T, Fitzsimmons ML, Lynch J: Breast cancer family history as a risk factor for early onset breast cancer. Breast Cancer Res Treat 11: 263–267, 1988

    Article  PubMed  Google Scholar 

  9. Claus EB, Risch N, Thompson WD: Genetic analysis of breast cancer in the cancer and steroid horomone study. Am J Human Genet 48: 232–242, 1991

    Google Scholar 

  10. Lynch HT, Conway T, Fitzgibbons R Jr, Schreiman J, Watson P, Marcus J, Fitzsimmons ML, Lynch JF: Age-of-onset heterogeneity in hereditary breast cancer: minimal clues for diagnosis. Breast Cancer Res Treat 12: 275–285, 1988

    Article  PubMed  Google Scholar 

  11. Lynch HT, Conway T, Watson P, Schreiman J, Fitzgibbons RJ Jr: Extremely early onset hereditary breast cancer: surveillance/management implications. Nebraska Med J 73: 97–100, 1988

    Google Scholar 

  12. Li FP, Fraumeni JF: Soft-tissue sarcomas, breast cancer and other neoplasms. Ann Int Med 71: 747–752, 1969

    PubMed  Google Scholar 

  13. Lynch HT, Krush AJ: Carcinoma of the breast and ovary in three families. Surg Gynecol Obstet 133: 644–648, 1971

    PubMed  Google Scholar 

  14. Lynch HT, Harris RE, Guirgis HA, Maloney K, Carmody LL, Lynch JF: Familial association of breast ovarian carcinoma. Cancer 41: 1543–1549, 1978

    PubMed  Google Scholar 

  15. Phipps RF, Perry PM: Familial breast cancer and the association with colonic carcinoma. Eur J Surg Oncol 15: 109–111, 1989

    PubMed  Google Scholar 

  16. Petritsch W, Pristautz H, Schreiber F, Stauber R, Kullnig P, Höfler H, Smolle J: Cowden-syndrom. Z Gastroenterol 28: 358–362, 1990

    PubMed  Google Scholar 

  17. Børresen A-L, Ikdahl Andersen T, Tretli S, Heiberg A, Møller P: Breast cancer and other cancers in Norwegian families with ataxia-telangiectasia. Genes Chrom and Cancer 2: 339–340, 1990

    Google Scholar 

  18. Swift M, Morrell D, Massey RB, Chase CL: Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325: 1831–1836, 1992

    Google Scholar 

  19. Iselius L, Littler M, Morton N: Transmission of breast cancer — a controversy resolved. Clin Genet 41: 211–217, 1992

    PubMed  Google Scholar 

  20. Goldstein AM, Amors CI: Segregation analysis of breast cancer from the cancer and steroid hormone study: histologic subtypes. J Natl Cancer Inst 82: 1911–1917, 1990

    PubMed  Google Scholar 

  21. Hall JM, Lee MK, Newman B, Morrow JE, Andersson LA, Huey B, King M-C: Linkage of early-onset familial breast cancer to chromosome 17q21. Science 250: 1684–1689, 1990

    PubMed  Google Scholar 

  22. Malkin D, Li FP, Strong LC, Fraumeni JF Jr, Nelson CE, Kim DH, Kassel J, Gryka MA, Bischoff FZ, Tainsky MA, Friend SH: Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science 259: 1233–1238, 1990

    Google Scholar 

  23. Srivastava S, Zou Z, Pirollo K, Blattner W, Chang EH: Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 348: 747–749, 1990

    Article  PubMed  Google Scholar 

  24. Love RR, Evans AM,et al.: The accuracy of patient reports of a family history of cancer. J Chronic Dis 38: 289–293, 1985

    Article  PubMed  Google Scholar 

  25. Snedecor GW, Cochran WG: Statistical Methods, 6th ed., 1967, Iowa, p 246

  26. Lynch HT, Fitzsimmons ML, Schreiman J, Conway T, Lynch JF: Breast cancer diagnosis in a putative obligate gene carrier. Cancer Genet Cytogenet 36: 205–210, 1988

    Article  PubMed  Google Scholar 

  27. Levine EG, King RA, Bloomfield CD: The role of heredity in cancer. J Clin Oncol 7: 527–540, 1989

    PubMed  Google Scholar 

  28. Adami HO, Hansen J, Jung B, Rimsten Å: Familiality in breast cancer: a case-control study in a Swedish population. Br J Cancer 42: 71–77, 1980

    PubMed  Google Scholar 

  29. Adami HO, Hansen J, Jung B, Rimsten Å: Characteristics of familial breast cancer in Sweden: absence of relation to age and unilateral versus bilateral disease. Cancer 48: 1688–1694, 1981

    PubMed  Google Scholar 

  30. Penrose LS, Mackenzie HJ, Karn MN: A genetical study of human mammary cancer. Ann Eugen 14: 234–266, 1948

    Google Scholar 

  31. Langlands AO, Kerr GR, Bloomer SM: Familial breast cancer. Clin Oncol 2: 41–45, 1976

    PubMed  Google Scholar 

  32. Lynch HT, Albano W, Recerbaren J, Lynch PM, Lynch JF, Elston R: Prolonged survival as a component of hereditary breast and nonpolyposis colon cancer. Med Hypothesis 7: 1201–1209, 1981

    Article  Google Scholar 

  33. Anderson DE, Badzioch MD: Survival in familial breast cancer patients. Cancer 58: 360–365, 1986

    PubMed  Google Scholar 

  34. Hall J: Genomic imprinting: review and relevance to human diseases. Am J Hum Genet 46: 857–873, 1990

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Genetics, Karolinska Hospital, S-104 01, Stockholm, Sweden

    Annika Lindblom, Catharina Larsson & Magnus Nordenskjöld

  2. Department of Surgery, Karolinska Hospital, S-104 01, Stockholm, Sweden

    Lennart Iselius

  3. Department of Oncology, Danderyds Hospital, S-182 88, Danderyd, Sweden

    Sam Rotstein

Authors
  1. Annika Lindblom
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sam Rotstein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Catharina Larsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Magnus Nordenskjöld
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Lennart Iselius
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lindblom, A., Rotstein, S., Larsson, C. et al. Hereditary breast cancer in sweden: a predominance of maternally inherited cases. Breast Cancer Res Tr 24, 159–165 (1992). https://doi.org/10.1007/BF01961248

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01961248

Key words

Search

Navigation