Abstract
The results of investigations carried out to evaluate the inhibitory activity in vitro of seven vaginal antiseptic douche solutions against several strains of vaginal lactobacilli isolated from asymptomatic women are reported. Some of the products examined showed marked antibacterial activity even at high dilutions and for short exposure times. The post-antibiotic effect of two of these antiseptics on vaginal lactobacilli was also evaluated. The results of these investigations suggest that uncontrolled use of antiseptic products could cause changes in the normal vaginal flora.
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Bartlett JG, Onderdonk AB, Drude E, Goldstein C, Anderka M, Alpert S, McCormack WM: Quantitative bacteriology of the vaginal flora. Journal of Infectious Disease 1977, 136: 271–277.
Goldacre MJ, Watt B, Loudon N, Milne LJ, Loudon JDO, Vessey MP: Vaginal microbial flora in normal young women. British Medical Journal 1979, i: 1450–1453.
Giorgi A, Torriani S, Dellaglio F, Bo G, Stola E, Bernuzzi L: Identification of vaginal lactobacilli from asymptomatic women. Microbiologica 1987, 10: 377–384.
Magliano EM, Clerici P, Bestetti ML: Ricerche sull' isolamento, la quantizzazione e la biotipizzazione della flora lattobacillare di provenienza vaginale. Bollettino dell' Istituto Sieroterapico Milanese 1984, 63: 331–337.
Sharpe ME: The genusLactobacillus. In: Starr MP, Stolp G, Trüber C, Balows H, Schlegel K (ed): The prokaryotes. Volume 2. Springer-Verlag, Berlin, 1981.
Eschenbach D: Vaginal infection. Clinical Obstetrics and Gynecology 1983, 26: 186.
Hanna NF: The relation between vaginal pH and the microbiological status in vaginitis. British Journal of Obstetrics and Gynecology 1985, 92: 1267–1271.
Klebanoff SJ, Hillier SL, Eschenbach DA, Waltersdorph AM: Control of the microbial flora of the vagina by H2O2 generating lactobacilli. Journal of Infectious Diseases 1991, 164: 94–100.
Vignini M, Pelfini C: Feminine hygiene both daily and in relation to sexual intercourse. Journal of Applied Cosmetology 1987, 5: 102.
Proto M, Cardinale F, Cortelazzi R: Controlli clinici e batteriologici dopo l'impiego di una lavanda vaginale monodose a base di salicaria. Giornale Italiano di Ostetricia e Ginecologia 1989, 1: 60–64.
Wolner-Hanssen P, Eschenbach DA, Paavonen J, Stevens CE, Kiviat NB, Critchlow C, DeRouen T, Koutsky L, Holmes KK: Association between vaginal douching and acute pelvic inflammatory disease. Journal of the American Medical Association 1990, 263: 1936–1941.
Piu L, Juliano C: Requisiti tecnologici ed attività “in vitro” di alcuni preparati antisettici per uso vaginale. L'Igiene Moderna 1990, 94: 688–700.
Juliano C, Piu L, Zanetti S: Requisiti tecnologici ed attività “in vitro” di alcuni preparati antisettici per us vaginale. Nota II. L'Igiene Moderna 1991, 95: 672–679.
Craig WA, Gudmundson S: The postantibiotic effect. In: Lorian V (ed): Antibiotics in laboratory medicine. William & Wilkins, Baltimore, 1986, p. 515–536.
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Juliano, C., Piu, L., Gavini, E. et al. In vitro antibacterial activity of antiseptics against vaginal lactobacilli. Eur. J. Clin. Microbiol. Infect. Dis. 11, 1166–1169 (1992). https://doi.org/10.1007/BF01961138
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DOI: https://doi.org/10.1007/BF01961138