Fatal necrotizing esophagitis due toPenicillium chrysogenum in a patient with acquired immunodeficiency syndrome

  • M. Hoffman
  • E. Bash
  • S. A. Berger
  • M. Burke
  • I. Yust


Although blue-green molds of the genusPenicillium are ubiquitous in the human environment, invasive penicilliosis is uncommon and primarily encountered among immunosuppressed patients. A patient with HIV infection who died of severe necrotizing esophagitis caused byPenicillium chrysogenum is reported and the relevant English language literature on human penicilliosis is reviewed. Although infectious esophagitis is commonly associated with AIDS,Penicillium esophagitis has not been described in such patients.


Internal Medicine English Language Esophagitis Acquire Immunodeficiency Syndrome Immunosuppressed Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Groopman JE: The acquired immunodeficiency syndrome. In: Wyngaarden JB, Smith LH (ed): Cecil textbook of medicine. Saunders, Philadelphia, 1988, p. 1799–1808.Google Scholar
  2. 2.
    Chamberland ME, Curran JW: Epidemiology and prevention of AIDS and HIV infection. In: Mandell GL, Douglas RG, Bennett JE (ed): Principles and practices of infectious diseases. Churchill Livingstone, New York, 1990, p. 1029–1046.Google Scholar
  3. 3.
    Rippon JW: Hyalohyphomycosis. In: Rippon JW (ed): Medical mycology. Saunders, Philadelphia, 1988, p. 728–730.Google Scholar
  4. 4.
    Jayanetra P, Nitiyanant P, Ajello L, Padhye AA, Lolekha S, Atichartakarn V, Vathesatogit P, Sathaphatayavongs B, Prajaktam R:Penicilliosis marneffei in Thailand: report of five human cases. American Journal of Tropical Medicine and Hygiene 1984, 33: 637–644.Google Scholar
  5. 5.
    Deng ZL, Ma Y, Ajello L: HumanPenicilliosis marneffei and its relation to the bamboo rat (Rhizomys pruinosus). Journal of Medicine and Veterinary Mycology 1986, 24: 383–389.Google Scholar
  6. 6.
    Deng ZL, Ribas JL, Gibson DW, Connor DH: Infections caused byPenicillium marneffei in China and Southeast Asia: review of eighteen published cases and report of four more Chinese cases. Review of Infectious Diseases 1988, 10: 640–652.Google Scholar
  7. 7.
    Cello JP: AIDS-associated gastrointestinal disease. In: Sande MA, Volberding PA (ed): The medical management of AIDS. Saunders, Philadelphia, 1990, p. 145–160.Google Scholar
  8. 8.
    Fenech FF, Mallia CP: Pleural effusion caused byPenicillium lilacinum. British Journal of Diseases of Chest 1972, 66: 284–290.Google Scholar
  9. 9.
    Schlueter DP: “Cheesewashers' disease”: a new occupational hazard? Annals of Internal Medicine 1973, 78: 606.Google Scholar
  10. 10.
    Smyth GDL: Fungal infection in otology. British Journal of Dermatology 1964, 76: 425–428.Google Scholar
  11. 11.
    Morriss FH, Spock A: Intracranial aneurysm secondary to mycotic orbital and sinus infection. American Journal of Diseases of Children 1970, 119: 357–362.Google Scholar
  12. 12.
    Eschete ML, King JW, West BC, Oberle A:Penicillium chrysogenum endophthalmitis: first reported case. Mycopathologia 1981, 74: 125–127.Google Scholar
  13. 13.
    Gilliam JS, Vest SA:Penicillium infection of the urinary tract. Journal of Urology 1951, 65: 484–489.Google Scholar
  14. 14.
    Huang SN, Harris LS: Acute disseminated penicillosis: report of a case and review of pertinent literature. American Journal of Clinical Pathology 1963, 39: 167–174.Google Scholar
  15. 15.
    Disalvo AF, Fickling AM, Ajello L: Infection caused byPenicillium marneffei: description of first natural infection in man. American Journal of Clinical Pathology 1973, 60: 259–263.Google Scholar
  16. 16.
    Peto TE, Bull R, Millard PR, Mackenzie DW, Campbell CK, Haines ME, Mitchell RG: Systemic mycosis due toPenicillium marneffei in a patient with antibody to human immunodeficiency virus. Journal of Infections 1988, 16: 285–290.Google Scholar
  17. 17.
    Piehl MR, Kaplan RL, Haber MH: Disseminated penicilliosis in a patient with acquired immunodeficiency syndrome. Archives of Pathology and Laboratory Medicine 1988, 112: 1262–1264.Google Scholar
  18. 18.
    Alvarez S: Systemic infection caused byPenicillium decumbens in a patient with acquired immunodeficiency syndrome. Journal of Infectious Diseases 1990, 162: 283.Google Scholar
  19. 19.
    Upshaw CB: Penicillium endocarditis of aortic valve prosthesis. Journal of Thoracic and Cardiovascular Surgeries 1974, 68: 428–431.Google Scholar

Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • M. Hoffman
    • 1
  • E. Bash
    • 2
  • S. A. Berger
    • 2
  • M. Burke
    • 1
  • I. Yust
    • 1
  1. 1.Department of Internal Medicine A, Clinical Immunology UnitTel-Aviv University, Sackler School of MedicineTel-AvivIsrael
  2. 2.Department of Microbiology, Sourasky Medical CenterTel-Aviv University, Sackler School of MedicineTel-AvivIsrael

Personalised recommendations