First reported case of streptococcus pyogenes infection with toxic shock-like syndrome in Italy

  • G. B. Cherchi
  • E. L. Kaplan
  • P. M. Schlievert
  • A. Bitti
  • G. Orefici


A 43-year-old male who sustained a superficial hand injury developed streptococcal toxic shock-like syndrome and died within 48 hours. The clinical course of the illness in this previously well patient was rapid and fulminant. The organism responsible was a group A beta-hemolytic streptococcus which was identified as opacity factor negative, M serotype 1, T type 1. The organism produced streptococcal pyrogenic exotoxins B and C, but no detectable exotoxin A although it carriedspeA, the gene for exotoxin A. This is the first case reported in Italy, and further emphasizes the virulence of these organisms and the rapidity with which the illness can progress.


Internal Medicine Hand Injury Streptococcal Pyrogenic Exotoxin Opacity Factor 
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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1992

Authors and Affiliations

  • G. B. Cherchi
    • 1
  • E. L. Kaplan
    • 2
  • P. M. Schlievert
    • 3
  • A. Bitti
    • 1
  • G. Orefici
    • 4
  1. 1.Laboratorio di Patologia ClinicaOzieriItaly
  2. 2.Department of PediatricsUniversity of Minnesota Medical SchoolMinneapolisUSA
  3. 3.Department of MicrobiologyUniversity of Minnesota Medical SchoolMinneapolisUSA
  4. 4.Laboratorio di Batteriologia e Micologia MedicaIstituto Superiore di SanitaRomeItaly

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