Abstract
The pyrogenic exotoxin profiles were determined of group A streptococci isolated from patients in Zagreb, Croatia in the period 1989–1990. A total of 12 strains were studied, five from patients with serious infections and seven from patients with uncomplicated infections. Serotypes M1 and M3 were found in seven (58 %) patients. Seven strains produced exotoxin A and ten strains exotoxin B. The proportion of exotoxin A and B producing strains in patients with severe infections (3 patients respectively) was similar to that found in patients with uncomplicated infections (4 and 7 patients respectively).
Similar content being viewed by others
References
Schwartz B, Facklam RR, Breiman RF: Changing epidemiology of group A streptococcal infection in the USA. Lancet 1990, 336: 1167–1171.
Kaplan EL: The resurgence of group A streptococcal infections and their sequelae. European Journal of Clinical Microbiology and Infectious Diseases 1991, 10: 55–57.
Köhler W: Streptococcal toxic shock syndrome. Zentralblatt für Bakteriologie 1990, 272: 257–264.
Martin PR, Hoiby EA: Streptococcal A epidemic in Norway 1987–1988. Scandinavian Journal of Infectious Diseases 1990, 22: 421–429.
Cone LA, Woodard DR, Schlievert PM, Tomory GS: Clinical and bacteriological observations of a toxicshock like syndrome due toStreptococcus pyogenes. New England Journal of Medicine 1987, 317: 146–149.
Stevens DL, Tanner MH, Winship J, Swarts R, Ries KM, Schlievert PM, Kaplan E: Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. New England Journal of Medicine 1989, 321: 1–7.
Gaworzewska ET, Hallas G: Group A streptococcal infections and a toxic shock-like syndrome. New England Journal of Medicine 1989, 321: 1546.
Begovac J, Gmajnički B, Kuzmanović N: Invasive streptococci. Lancet 1990, 335: 109.
Begovac J, Marton E, Lisić M, Beus I, Božinović D, Kuzmanović N: Group A beta-hemolytic streptococcal toxic shock-like syndrome. Pediatric Infectious Disease Journal 1990, 9: 369–370.
Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 1975, 98: 503–517.
Johnson LP, Tomai MA, Schlievert PM: Bacteriophage involvement in group A streptococcal pyrogenic exotoxin A production. Journal of Bacteriology 1986, 166: 623–627.
Goshorn SG, Bohach GA, Schlievert PM: Cloning and characterisation of the gene,speC for pyrogenic exotoxin type C fromStreptococcus pyogenes. Molecular and General Genetics 1988, 212: 66–70.
Hallas G: The production of pyrogenic exotoxins by group A streptococci. Journal of Hygiene 1985, 95: 47–57.
Yu CE, Ferretti JJ: Frequency of the erythrogenic toxin B and C genes (speB andspeC) among clinical isolates of group A streptococci. Infection and Immunity 1991, 59: 211–215.
Chomarat M, Chapius C, Lepape A, Bernard F: Two cases of severe infection with beta-haemolytic group A streptococci associated with a toxic-shock-like syndrome. European Journal of Clinical Microbiology and Infectious Diseases 1990, 9: 901–903.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Begovac, J., Gmajnicki, B., Schlievert, P.M. et al. Production of pyrogenic exotoxins in group a streptococci isolated from patients in Zagreb, Croatia. Eur. J. Clin. Microbiol. Infect. Dis. 11, 540–543 (1992). https://doi.org/10.1007/BF01960810
Issue Date:
DOI: https://doi.org/10.1007/BF01960810