Skip to main content
Log in

Production of pyrogenic exotoxins in group a streptococci isolated from patients in Zagreb, Croatia

  • Notes
  • Published:
European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The pyrogenic exotoxin profiles were determined of group A streptococci isolated from patients in Zagreb, Croatia in the period 1989–1990. A total of 12 strains were studied, five from patients with serious infections and seven from patients with uncomplicated infections. Serotypes M1 and M3 were found in seven (58 %) patients. Seven strains produced exotoxin A and ten strains exotoxin B. The proportion of exotoxin A and B producing strains in patients with severe infections (3 patients respectively) was similar to that found in patients with uncomplicated infections (4 and 7 patients respectively).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Schwartz B, Facklam RR, Breiman RF: Changing epidemiology of group A streptococcal infection in the USA. Lancet 1990, 336: 1167–1171.

    PubMed  Google Scholar 

  2. Kaplan EL: The resurgence of group A streptococcal infections and their sequelae. European Journal of Clinical Microbiology and Infectious Diseases 1991, 10: 55–57.

    Google Scholar 

  3. Köhler W: Streptococcal toxic shock syndrome. Zentralblatt für Bakteriologie 1990, 272: 257–264.

    Google Scholar 

  4. Martin PR, Hoiby EA: Streptococcal A epidemic in Norway 1987–1988. Scandinavian Journal of Infectious Diseases 1990, 22: 421–429.

    PubMed  Google Scholar 

  5. Cone LA, Woodard DR, Schlievert PM, Tomory GS: Clinical and bacteriological observations of a toxicshock like syndrome due toStreptococcus pyogenes. New England Journal of Medicine 1987, 317: 146–149.

    PubMed  Google Scholar 

  6. Stevens DL, Tanner MH, Winship J, Swarts R, Ries KM, Schlievert PM, Kaplan E: Severe group A streptococcal infections associated with a toxic shock-like syndrome and scarlet fever toxin A. New England Journal of Medicine 1989, 321: 1–7.

    PubMed  Google Scholar 

  7. Gaworzewska ET, Hallas G: Group A streptococcal infections and a toxic shock-like syndrome. New England Journal of Medicine 1989, 321: 1546.

    Google Scholar 

  8. Begovac J, Gmajnički B, Kuzmanović N: Invasive streptococci. Lancet 1990, 335: 109.

    Google Scholar 

  9. Begovac J, Marton E, Lisić M, Beus I, Božinović D, Kuzmanović N: Group A beta-hemolytic streptococcal toxic shock-like syndrome. Pediatric Infectious Disease Journal 1990, 9: 369–370.

    PubMed  Google Scholar 

  10. Southern EM: Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology 1975, 98: 503–517.

    PubMed  Google Scholar 

  11. Johnson LP, Tomai MA, Schlievert PM: Bacteriophage involvement in group A streptococcal pyrogenic exotoxin A production. Journal of Bacteriology 1986, 166: 623–627.

    PubMed  Google Scholar 

  12. Goshorn SG, Bohach GA, Schlievert PM: Cloning and characterisation of the gene,speC for pyrogenic exotoxin type C fromStreptococcus pyogenes. Molecular and General Genetics 1988, 212: 66–70.

    PubMed  Google Scholar 

  13. Hallas G: The production of pyrogenic exotoxins by group A streptococci. Journal of Hygiene 1985, 95: 47–57.

    PubMed  Google Scholar 

  14. Yu CE, Ferretti JJ: Frequency of the erythrogenic toxin B and C genes (speB andspeC) among clinical isolates of group A streptococci. Infection and Immunity 1991, 59: 211–215.

    PubMed  Google Scholar 

  15. Chomarat M, Chapius C, Lepape A, Bernard F: Two cases of severe infection with beta-haemolytic group A streptococci associated with a toxic-shock-like syndrome. European Journal of Clinical Microbiology and Infectious Diseases 1990, 9: 901–903.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Begovac, J., Gmajnicki, B., Schlievert, P.M. et al. Production of pyrogenic exotoxins in group a streptococci isolated from patients in Zagreb, Croatia. Eur. J. Clin. Microbiol. Infect. Dis. 11, 540–543 (1992). https://doi.org/10.1007/BF01960810

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01960810

Keywords

Navigation