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Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate

Experientia volume 35, pages 696–699 (1979)Cite this article

Summary

Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) antagonized the effect of exogenous androgens on the ventral prostate (VP) in castrated rats as well as the effect of endogenous androgens in intact rats. FA, however, had no effect on the seminal vesicles (SV) and levator ani muscle (LAM), nor oestrogenic effect in female rats and mice. FA did not antagonize the receptor binding of testosterone nor inhibit the conversion of testosterone into 5α-dihydrotestosterone (DHT).

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References

  1. L. G.Hirschberger, E. G. Shipley and R. K. Meyer, Proc. Soc. exp. Biol. N. Y.83, 175 (1953).

    Google Scholar 

  2. B. T. Rubin, A. S. Dorfman, L. Black and R. I. Dorfman, Endocrinology49, 429 (1951).

    Google Scholar 

  3. M. X. Zarrow, J. M. Yochim and J. L. McCarthy, in: Experimental Endocrinology, p. 40. Academic Press, New York 1964.

    Google Scholar 

  4. N. Bruchovsky, P. S. Rennie and A. Vanson, Biochim. biophys. Acta394, 248 (1975).

    Google Scholar 

  5. K. Burton, in: Methods in Enzymology, XII, part B, p. 163. Academic Press, New York 1968.

    Google Scholar 

  6. O. H. Lowry, N. J. Rosebrough, A. L. Farr and R. J. Randall, J. biol. Chem.193, 265 (1951).

    Google Scholar 

  7. D. K. H. Lee, J. C. Young, Y. Tamura, D. C. Patterson, C. E. Bird and A. F. Clark, Can. J. Biochem.51, 735 (1973).

    Google Scholar 

  8. P. B. Coulson and E. J. Pavlik, J. Steroid Biochem.8, 205 (1977).

    Google Scholar 

  9. H. J. Helminen and J. L. E. Ericsson, J. Ultrastr. Res.36, 708 (1971).

    Google Scholar 

  10. D. Brandes, in: Male Accessory Sex Organs, p. 184. Academic Press, New York 1974.

    Google Scholar 

  11. H. Chiodi, C. r. Soc. Biol. (Paris),129, 866 (1938).

    Google Scholar 

  12. H. Chiodi, C. r. Soc. Biol. (Paris)130, 457 (1939).

    Google Scholar 

  13. K. Korenchevsky, K. Hall and M. A. Ross, Biochem. J.31, 467 (1937).

    Google Scholar 

  14. H. C. Browning, I. K. Hawkins and L. M. Holmberg, Texas Rep. Biol. Med.19, 753 (1961).

    Google Scholar 

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Author information

Affiliations

  1. Department of Pharmacology, Kawasaki Medical School, 701-01, Kurashiki, (Japan)

    T. Saito, T. Nohno, H. Yoshida & H. Yokoya

  2. Department of Pharmacology, Iwate Medical University School of Dentistry, 020, Morioka, (Japan)

    T. Saito, T. Nohno, H. Yoshida & H. Yokoya

Authors
  1. T. Saito
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  2. T. Nohno
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  3. H. Yoshida
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  4. H. Yokoya
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Additional information

Supported in part by the project fund (grant 53-403) of Kawasaki Medical School.

The authors would like to thank the Central Laboratory, Sankyo Pharmaceutical Co., Tokyo, for supplying 19-nortestosterone-17-ferulate.

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Saito, T., Nohno, T., Yoshida, H. et al. Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate. Experientia 35, 696–699 (1979). https://doi.org/10.1007/BF01960405

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  • DOI: https://doi.org/10.1007/BF01960405

Keywords

  • Testosterone
  • Androgen
  • Receptor Binding
  • Ferulic Acid
  • Seminal Vesicle