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Experientia

, Volume 35, Issue 5, pp 666–668 | Cite as

Promotion of epithelial keratinization by N-methyl-N′-nitro-N-nitrosoguanidine in rat forestomach in organ culture

  • H. Fukamachi
  • S. Takayama
Article

Summary

The effect of N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) on epithelial differentiation of fetal rat forestomach was investigated in organ culture. When forestomach tissues removed from 16.5-day fetuses were treated with 5 μg and 3 μg of MNNG per ml for 1 h, epithelial keratinization was observed after 4 and 5 days, respectively, whereas it occurred after 6 days in control cultures. A clear dose-response relationship was found in the promotion of epithelial keratinization by MNNG.

Keywords

Organ Culture Control Culture Epithelial Differentiation Epithelial Keratinization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • H. Fukamachi
    • 1
    • 2
  • S. Takayama
    • 1
    • 2
  1. 1.Zoological Institute, Faculty of ScienceUniversity of TokyoTokyo
  2. 2.Department of Experimental PathologyCancer InstituteTokyo(Japan)

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