Summary
In the rabbit isolated aorta, hymenin (10−6 M) a novel marine alkaloid, caused a parallel rightward shift of the dose-response curve for norepinephrine without affecting that for histamine or KCl, suggesting that hymenin is a competitive antagonist of α-adrenoceptors in vascular smooth muscles.
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Acknowledgments. We thank Ms A. Kajiwara and Ms M. Hamashima of this institute for their technical assistance, and Prof. Y. Hirata of Meijo University for his encouragement.
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Kobayashi, J., Nakamura, H. & Ohizumi, Y. α-Adrenoceptor blocking action of hymenin, a novel marine alkaloid. Experientia 44, 86–87 (1988). https://doi.org/10.1007/BF01960260
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DOI: https://doi.org/10.1007/BF01960260