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Steroid hormones enhanced sister-chromatid exchange in cultured CHO cells

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The influence of steroid hormones on the induction of sister-chromatid exchange (SCE) in cultured CHO cells was studied. It was observed that estradiol-17 β, estriol, estrone and ethynyl estradiol treatments enhanced SCE rates compared to the controls. Overall, these compounds produced a dose response effect. The importance of a detailed study on the long-term genetic effects of steroids on mammalian cells is emphasized.

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Authors and Affiliations

  1. Biology Area, Division of Mathematics and Sciences, Kentucky State University, 40601, Frankfort, Kentucky, USA

    T. S. Kochhar

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  1. T. S. Kochhar
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Additional information

This work was supported by NIH-Minority Biomedical Research Support Program (MBRS), Grant No. RR 08124-11. The author is thankful for the technical assistance provided by NIH-MBRS student, Hoang Duong.

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Kochhar, T.S. Steroid hormones enhanced sister-chromatid exchange in cultured CHO cells. Experientia 44, 62–63 (1988). https://doi.org/10.1007/BF01960247

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