, Volume 44, Issue 1, pp 52–55 | Cite as

Aberrant protamine 1/protamine 2 ratios in sperm of infertile human males

  • R. Balhorn
  • S. Reed
  • N. Tanphaichitr
Short Communications


Protamines were extracted from the sperm of fertile and infertile human males and the relative proportion of protamines 1, 2, and 3 were determined by scanning microdensitometry following electrophoresis of total protamine in polyacrylamide gels. The proportion of the three protamines was found to be similar in sperm obtained from different normal males. The distribution of protamines in sperm obtained from a select group of infertile males producing an elevated level of large sperm heads, in contrast, was different from that of the fertile males.

Key words

Human sperm human protamine protamine 1 protamine 2 protamine 3 infertility gene expression 


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Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • R. Balhorn
    • 1
  • S. Reed
    • 2
  • N. Tanphaichitr
    • 3
  1. 1.Biomedical Sciences DivisionL-452 Lawrence Livermore National LaboratoryLivermoreUSA
  2. 2.Matanzas Creek WinerySanta RosaUSA
  3. 3.Departments of Obstetrics and Gynecology and Anatomy and Cellular Biology, Harvard Medical School, Dana Biomedical Research InstituteBeth Israel HospitalBostonUSA

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