Experientia

, Volume 44, Issue 1, pp 38–40 | Cite as

Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin

  • J. R. WrightJr
  • J. Mendola
  • P. E. Lacy
Short Communications

Summary

Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.

Key words

Streptozotocin diabetes mellitus NAD niacin nicotinamide tryptophan CD-1 mice 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Rerup, C.C., Pharmac. Rev.22 (1970) 485.Google Scholar
  2. 2.
    Chang, A.Y., and Diani, A.R., in: The Diabetic Pancreas, p. 415. Plenum Medical Book New York 1985.Google Scholar
  3. 3.
    Schein, P.S., Cooney, D.A., and Vernon, M.L., Cancer Res.27 (1967) 2324.PubMedGoogle Scholar
  4. 4.
    Dulin, W.E., and Wyse, B.M., Proc. Soc. exp. Biol. Med.130 (1969) 992.PubMedGoogle Scholar
  5. 5.
    Ho, C.K., and Hashim, S.A., Diabetes21 (1972) 789.PubMedGoogle Scholar
  6. 6.
    Hinz, M., Katsilambros, N., Maier, V., Schatz, H., and Pfeiffer, E.F., FEBS Lett.30 (1973) 225.CrossRefPubMedGoogle Scholar
  7. 7.
    Lazarus, S.S., and Shapiro, S.H., Diabetes.22 (1973) 499.PubMedGoogle Scholar
  8. 8.
    Anderson, T., Schein, P.S., McMenamin, M.G., and Cooney, D.A., J. clin. Invest.54 (1974) 672.PubMedGoogle Scholar
  9. 9.
    Schein, P.S., Cooney, D.A., McMenamin, M.G., and Anderson, T., Biochem. Pharmac.22 (1973) 2625.CrossRefGoogle Scholar
  10. 10.
    Stauffacher, W., Burr, I., Gutzeit, A., Beaven, D., Veleminsky, J., and Renold, A.E., Proc. Soc. exp. Biol. Med.133 (1974) 194.Google Scholar
  11. 11.
    LeDoux, S.P., and Wilson, G.L., Biochim. biophys. Acta804 (1984) 387.CrossRefPubMedGoogle Scholar
  12. 12.
    LeDoux, S.P., Woodley, S.E., Patton, N.J., and Wilson, G.I., Diabetes35 (1986) 866.PubMedGoogle Scholar
  13. 13.
    Yamamoto, H., Uchigata, Y., and Okamoto, H., Nature294 (1981) 284.CrossRefPubMedGoogle Scholar
  14. 14.
    Okamoto, H., Bioessays,2 (1985) 15.CrossRefGoogle Scholar
  15. 15.
    Okamoto, H., Biomed. biochim. Acta44 (1985) 15.PubMedGoogle Scholar
  16. 16.
    Weiner, M., and Van Eys J. Nicotinic Acid: Nutrient-Cofactor-Drug p. 17. Marcel Dekker New York 1983.Google Scholar
  17. 17.
    Uchigata, Y., Yamamota, H., Kawamura, A., and Okamoto, H., J biol. Chem. 257 (1982) 6088.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • J. R. WrightJr
    • 1
  • J. Mendola
    • 1
    • 2
  • P. E. Lacy
    • 1
  1. 1.Department of PathologyWashington University School of MedicineSt. LouisUSA
  2. 2.Diabetes UnitBarcelona University School of MedicineBarcelonaSpain

Personalised recommendations