, Volume 44, Issue 1, pp 38–40 | Cite as

Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin

  • J. R. WrightJr
  • J. Mendola
  • P. E. Lacy
Short Communications


Weanling CD-1 mice were fed either a control diet or a diet deficient in niacin/nicotinamide for one month and then injected i.v. with 60, 80, 100, 120, 140, or 160 mg/kg streptozotocin. Mice on the deficient diet developed a higher incidence of diabetes and more severe hyperglycemia than those on the control diet.

Key words

Streptozotocin diabetes mellitus NAD niacin nicotinamide tryptophan CD-1 mice 


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Copyright information

© Birkhäuser Verlag Basel 1988

Authors and Affiliations

  • J. R. WrightJr
    • 1
  • J. Mendola
    • 1
    • 2
  • P. E. Lacy
    • 1
  1. 1.Department of PathologyWashington University School of MedicineSt. LouisUSA
  2. 2.Diabetes UnitBarcelona University School of MedicineBarcelonaSpain

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